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Third generation antipsychotic drugs: partial agonism or receptor functional selectivity?
The D(2) functional selectivity hypothesis can accommodate all current data for aripiprazole, and also impacts on discovery compounds that are not pure D( 2) antagonists, as well as those that also bind with modest affinity to 5-HT(2A), and many other neuroreceptors. Expand
Post-operative cognitive dysfunction in the elderly: A prospective clinical study
Gender emerged as a significant risk factor with increasing age as a dominating factor contributing to POCD, while type of anaesthesia, duration of surgery, and presence of coexisting comorbidities had no influence on the incidence of cognitive dysfunction. Expand
SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase C
- Sang-Min Lee, A. Kant, D. Blake, V. Murthy, R. Mailman
- Medicine, Biology
- 1 November 2014
Data demonstrate that SKF-83959 is not a highly-biased functionally selective D1 ligand, and that its reported behavioral data can be explained solely by its partial D1 agonism in canonical signaling pathway(s). Expand
Vildagliptin: an anti‐diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin‐induced Alzheimer's disease
- Jayasankar Kosaraju, V. Murthy, +4 authors D. Basavan
- Chemistry, Medicine
- The Journal of pharmacy and pharmacology
- 1 December 2013
The present study investigates the efficacy of vildagliptin, a DPP‐4 inhibitor in a streptozotocin (STZ)‐induced rat model of AD. Expand
Ligand functional selectivity advances our understanding of drug mechanisms and drug discovery
The question is whether functional selectivity is an interesting artifact for the specialist, or a mechanism that affects psychoactive drug action and drug discovery, and the data suggest that both are true, which permits a greater understanding of the differential neuropsychopharmacology of drugs once thought to be functionally similar. Expand
In Vivo Characterization of a Novel Phenylisothiocyanate Tropane Analog at Monoamine Transporters in Rat Brain
- V. Murthy, T. Martin, Susy A. Kim, H. Davies, S. Childers
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 August 2008
The irreversible effects of HD-205 in vivo in rats after intracranial injection was evaluated to evaluate the neuroanatomical basis of DAT-mediated cocaine effects and a strategy of site-specific chemical blockade of transporters was proposed. Expand
5-Aminosalicylic acid attenuates allergen-induced airway inflammation and oxidative stress in asthma.
- K. R. Raju, M. Kumar, +10 authors K. Elango
- Chemistry, Medicine
- Pulmonary pharmacology & therapeutics
- 1 December 2014
Findings suggest that 5-ASA is a potent immunomodulator and suppresses key Th2 cytokines production and oxidative stress in OVA-induced asthma. Expand
Preclinical Studies on Neurobehavioral and Neuromuscular Effects of Cocaine Hydrolase Gene Therapy in Mice
- V. Murthy, Y. Gao, L. Geng, N. LeBrasseur, T. White, S. Brimijoin
- Biology, Medicine
- Journal of Molecular Neuroscience
- 1 July 2014
Neither the viral vectors nor the large excess of BChE caused observable toxic effects on the motor and cognitive systems investigated, which justifies further steps toward an eventual clinical trial of vector-based gene transfer for cocaine abuse. Expand
Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice.
Viral gene transfer of BChE appears benign and worth exploring as a therapy for cocaine abuse and possibly other disorders as well, and neither the tested vectors nor great excesses of circulating B ChE affect general physiology directly, while they protect mice from disturbance by cocaine. Expand
Salicylic acid derivatives as potential anti asthmatic agents using disease responsive drug delivery system for prophylactic therapy of allergic asthma.
5-ASA and sodium salicylate loaded liposomes incorporated into PEG-4-acrylate and CCRGGC microgels could probably suit the needs for developing a disease responsive drug delivery system which will serve as a prophylactic therapy for asthmatic patients. Expand