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KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles.
The cloned from rat brain the cDNA encoding an 89,828-Da kinesin-related polypeptide KIF3C that is enriched in brain, retina, and lung is suggested to be a vesicle-associated motor that functions both independently and in association with Kif3A. Expand
The Kinesin Motor KIF3A Is a Component of the Presynaptic Ribbon in Vertebrate Photoreceptors
Findings suggest that within a single cell, the photoreceptor, one kinesin polypeptide, KIF3A, can serve two distinct functions, one specific for ribbon synapses. Expand
Dynactin-dependent, dynein-driven vesicle transport in the absence of membrane proteins: a role for spectrin and acidic phospholipids.
It is shown that spectrin is required for linking dynactin, and thereby dynein, to acidic phospholipids in the membrane, and verified in the context of liposomes, isolated axonal vesicles, and whole axoplasm. Expand
Gamma-tubulin in differentiated cell types: localization in the vicinity of basal bodies in retinal photoreceptors and ciliated epithelia.
Results suggest that this key centrosomal protein of mitotically active cells is also an integral component of microtubule organizing centers, required for the generation of the microtubules network in terminally differentiated cells. Expand
Plus-end motors override minus-end motors during transport of squid axon vesicles on microtubules
The finding that kinesin overrides cytoplasmic dynein when both are bound to bead surfaces indicates that the direction of vesicle movement could be regulated simply by the presence or absence of a tightly bound, plus-end kinesIn motor. Expand
Evidence for kinesin-related proteins associated with the axoneme of retinal photoreceptors.
Immunofluorescence microscopy of whole-mounted axonemes with the two anti-kinesin antibodies showed labeling throughout the axoneme, including the connecting cilium-basal body region, suggesting that the identified proteins may serve as motor molecules for transport of material to the outer segment via the connectingcilium. Expand
Complex intermolecular interactions maintain a stable linkage between the photoreceptor connecting cilium axoneme and plasma membrane.
The results suggest that the previously characterized cross-linker glycoconjugates are complex, SDS-resistant multi-molecular conglomerates. Expand
Intracellular fate of a multivalent ligand covalently bound to cell surface components. An electron microscopic study.
  • V. Mureşan
  • Biology, Medicine
  • Journal of submicroscopic cytology
  • 1 July 1987
It is concluded that FH, being unable to dissociate from its binding sites, is stopped on the endocytotic route in a compartment prior to its delivery to multivesicular bodies, thus escaping lysosomal degradation. Expand
Cell surface properties of normal, differentiating, and neoplastic pancreatic acinar cells
It is hypothesized that pancreatic cancers may arise from the equivalent of the undifferentiated embryonic stem cell(s) and that the morphologic features of the tumor depend on the extent of cell differentiation, including expression of cell‐surface glycoproteins and extracellular matrix, prior to neoplastic proliferation. Expand
Distribution of sialoglycoconjugates on acinar cells of the mammalian pancreas.
Results suggest that LPA binding sites on the acinar cell apical surface may be primarily sialoglycoproteins, while those on the basolateral surfaces may consist in part of gangliosides. Expand