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Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
The biosynthesis and release of nitric oxide (NO) and prostaglandins (PGs) share a number of similarities. Two major forms of nitric-oxide synthase (NOS) and cyclooxygenase (COX) enzymes have beenExpand
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A Newly Identified Role for Superoxide in Inflammatory Pain
Novel classes of pain-relieving molecules are needed to fill the void between nonsteroidal anti-inflammatory agents and narcotics. Our studies have identified superoxide as a novel mediator ofExpand
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Regulation of uric acid metabolism and excretion.
Purines perform many important functions in the cell, being the formation of the monomeric precursors of nucleic acids DNA and RNA the most relevant one. Purines which also contribute to modulateExpand
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Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies.
Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats andExpand
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Oxidative stress and neuroAIDS: triggers, modulators and novel antioxidants
Neurological disorders represent one of the most common disturbances accompanying HIV infection. In the past few years, highly antiretroviral active therapy has significantly reduced the incidence ofExpand
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Superoxide-mediated nitration of spinal manganese superoxide dismutase: a novel pathway in N-methyl-d-aspartate-mediated hyperalgesia
&NA; N‐methyl‐d‐aspartate (NMDA) receptors serve prominent roles in vast physio‐pathological conditions including hyperalgesia (defined as augmented pain intensity in response to painful stimuli)Expand
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Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice.
Severe pain syndromes reduce quality of life in patients with inflammatory and neoplastic diseases, often because chronic opiate therapy results in reduced analgesic effectiveness, or tolerance,Expand
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Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications.
The nitric oxide (NO) and cyclooxygenase (COX) pathways share a number of similarities. Nitric oxide is the mediator generated from the NO synthase (NOS) pathway, and COX converts arachidonic acid toExpand
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Defective Autophagy in Parkinson’s Disease: Role of Oxidative Stress
Parkinson’s disease (PD) is a paradigmatic example of neurodegenerative disorder with a critical role of oxidative stress in its etiopathogenesis. Genetic susceptibility factors of PD, such asExpand
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The effect of nitric oxide on cytokine‐induced release of PGE2 by human cultured astroglial cells
The role of the L‐arginine‐nitric oxide (NO) pathway on the formation of prostaglandin E2 (PGE2) by human cultured astroglial cells incubated with interleukin‐1β (IL‐1β) and tumour necrosis factor‐αExpand
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