Share This Author
The profile of mutational clusters associated with lamivudine resistance can be constrained by HBV genotypes.
Geographical reconstruction of the SARS‐CoV‐2 outbreak in Lombardy (Italy) during the early phase
This epidemiological reconstruction suggests that virus initial circulation in Lombardy was ascribable to multiple introduction, supporting the hypothesis that different SARS‐CoV‐2 strains had spread worldwide at different times, but their presence became evident only in late February along with Italian epidemic emergence.
Off-label use of tocilizumab for the treatment of SARS-CoV-2 pneumonia in Milan, Italy
Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen.
Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection.
Variations in Reverse Transcriptase and RNase H Domain Mutations in Human Immunodeficiency Virus Type 1 Clinical Isolates Are Associated with Divergent Phenotypic Resistance to Zidovudine
The results showed that viruses from patients failing multiple NRTI-containing regimens had distinct TAM and NAM profiles that conferred various degrees of resistance to ZDV, and the simultaneous presence of the L74V and M184V mutations was the most significant determinant of phenotypic resistance toZDV in patients infected with viruses with TAMs.
High burden of transmitted HIV-1 drug resistance in Italian patients carrying F1 subtype.
- M. Franzetti, A. Lai, C. Balotta
- Medicine, BiologyThe Journal of antimicrobial chemotherapy
- 1 May 2012
The study shows a remarkable frequency of TDR in the F1 subtype-infected population, with high prevalence detected in South American subjects and considerably high also in Italian subjects harbouring the F 1 subtype, deserving careful monitoring.
Multiclass HCV resistance to direct‐acting antiviral failure in real‐life patients advocates for tailored second‐line therapies
- V. D. di Maio, V. Cento, F. Ceccherini‐Silberstein
- Medicine, BiologyLiver international (Print)
- 20 January 2017
This study aimed to characterize the presence of clinically relevant RASs to all classes in real‐life DAA failures, and found that all classes of DAA patients had at least one RAS in their treatment regimens.
Combined Analysis of the Prevalence of Drug-Resistant Hepatitis B Virus in Antiviral Therapy-Experienced Patients in Europe (CAPRE).
These findings support resistance testing in cases of apparent NA therapy failure and highlight the impact of exposure to lamivudine and adefovir on development of drug resistance and cross-resistance.
Direct‐acting antivirals in hepatitis C virus (HCV)‐infected and HCV/HIV‐coinfected patients: real‐life safety and efficacy
Evaluated the safety and efficacy of all‐oral direct‐acting antivirals for chronic hepatitis C virus (HCV) infection in a clinical practice setting.