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Phthalates: toxicology and exposure.
TLDR
This paper presents an overview on current risk assessments done by expert panels as well as on exposure assessment data, based on ambient and on current human biomonitoring results, that prove that the tolerable intake of children is exceeded to a considerable degree. Expand
SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest).
TLDR
The SOS chromotest, using E. coli PQ37, was able to detect correctly most of the Salmonella mutagens and non-mutagens, and for 17 of 20 compounds, the results obtained could be compared to those obtained in the Ames test. Expand
Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test.
TLDR
The biodegradability of some clinically important antibiotic drugs and the elimination of their genotoxicity was investigated as the first step of an environmental risk assessment using the Closed Bottle test (CBT) (OECD 301 D) and the SOS chromotest. Expand
The use of the alkaline comet assay with lymphocytes in human biomonitoring studies.
TLDR
For the alkaline comet assay to be an important tool in human biomonitoring studies, serious consideration should be given to the flaws in the design and performance of the assay. Expand
Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens.
TLDR
Hep G2 cells have been used in antimutagenicity studies and can identify mechanisms not detected in conventional in vitro systems such as induction of detoxifying enzymes, inactivation of endogenously formed DNA-reactive metabolites and intracellular inhibition of activating enzymes. Expand
Apoptosis induction in human lung adenocarcinoma cells by oil‐soluble allyl sulfides: Triggers, pathways, and modulators
TLDR
It is reported that OASs DADS and DATS induce significant apoptosis in human lung adenocarcinoma A549 cells, whereas DAS does not, and the first evidence that Fas‐ mediated cell death pathway is partly involved in DADS but not DATS‐mediated cell death is provided. Expand
Genotoxicity of polycyclic aromatic hydrocarbons in Escherichia coli PQ37.
TLDR
In the present investigation, 32 polycyclic aromatic hydrocarbons (PAHs) were tested for genotoxicity in E. coli PQ37 using the standard tube assay of the SOS chromotest and the results were compared to those obtained with the Salmonella/microsome test. Expand
Genotoxic effects of three Fusarium mycotoxins, fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes.
TLDR
This is the first report on clastogenic effects of VOM and FB1 in mammalian cells, with MON induction of CAs in V-79 cells has been described earlier, since all three mycotoxins caused CAs at very low concentration levels in liver cells in vitro. Expand
Cytotoxicity and genotoxicity of size-fractionated iron oxide (magnetite) in A549 human lung epithelial cells: role of ROS, JNK, and NF-κB.
TLDR
These experiments suggest that ROS formation may play an important role in the genotoxicity of magnetite in A549 cells but that activation of JNK seems to be ROS-independent. Expand
Genotoxic effects of three selected black toner powders and their dimethyl sulfoxide extracts in cultured human epithelial A549 lung cells in vitro
TLDR
The overall results of the in‐vitro study suggest that the investigated toner‐powder samples are not cytotoxic but genotoxic, and metals and metalloids as components of magnetite, or PAHs as component of the carbon‐bearing material, are responsible for the genot toxic effects. Expand
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