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Clustering of discrete cell properties essential for tumorigenicity and metastasis. II. Studies of syrian hamster embryo fibroblasts transformed by rous sarcoma virus
Inhibition of H2OR2 + PGEs+ phenotype in one of RSV‐SR transformants was obtained with non‐toxic doses of BCNU and indomethacin, leading to a marked decrease of TGA. Expand
The role of glycosphingolipids in natural immunity. gangliosides modulate the cytotoxicity of natural killer cells
It is suggested that target cell‐associated gangliosides may function as target structures recognized by NK cells while serum ganglioides may contribute to the inhibition of NK cells during tumor development and thus help the tumor to escape NK surveillance. Expand
Clustering of discrete cell properties essential for tumorigenicity and metastasis. I. Studies of syrian hamster embryo fibroblasts spontaneously transformed in vitro
These two biochemically unrelated cell phenotypic characteristics are likely to be either simultaneously selected in vivo, or united in cluster which pre‐exist or appear in rare cell variants of the parental cell population in the conditions of in vivo natural selection pressure. Expand
Cell transforming genes and tumor progression: In vivo unified secondary phenotypic cell changes
Common secondary src‐like phenotypic cell changes, regardless of initially cell transforming genes are necessarily selected during tumor progression in vivo. Expand
Allogeneic bone‐marrow transfusion suppresses development of lung metastases in osteogenic sarcoma patients after radical surgery
Rapid recovery of NK cytotoxic activity has been observed in nearly all successfully BMC‐treated patients and the differences in the frequency of metastasis and duration of survival without metastasis of treated patients compared with a group of 41 osteogenic sarcoma patients reached significant levels 12 months after treatment and thereafter. Expand
Inhibition of experimental and spontaneous lung metastases of highly metastatic syrian hamster sarcoma cells by non‐activated bone marrow and peritoneal exudate cells
Retroorbital inoculation of Syrian hamsters with native, or lethally irradiated allogeneic BMC and PEC, but not spleen cells, or hamster embryo cells effectively inhibited the development of experimental and spontaneous lung metastases induced by STHE‐LM8 cells in the animals. Expand
Clustering of discrete cell properties essential for tumorigenicity and metastasis. III. Dissociation of the properties in N‐ras‐transfected rsv‐SR‐transformed cells
It is shown that transfection of 3 RSV‐SR‐transformed cell strains with activated N‐ras leads either to complete inhibition of the H2OR2 + PGES phenotype in all clones of one strain, or to inhibition of PGES only in the majority of clones of 2 other strains. Expand
Reproducibility and relation to specific and non‐specific anti‐tumor resistance of the tumor “sneaking through” phenomenon
The preliminary data demonstrate that abrogation of natural anti‐tumor resistance in adult hamsters subsequently inoculated with SV40 leads to rapid development of primary tumors in such animals. Expand
In vitro bioassay for type E prostaglandins based on their NK immunodepressing activity.
A biological assay for PGE in commercial preparations, or secreted by tumor cells in culture fluid was developed on the basis of the immunosuppressive effect of PGE on the cytotoxic activity of NKExpand
Sensitivity of TSTA and species-specific cell membrane antigens of tumor cells to glutaraldehyde treatment.
Two different syngeneic Syrian hamster transplantable tumor cell lines not only lost immunogenicity after GA treatment but were responsible for enhancement of test-tumor growth in immunized animals. Expand