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Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers.
The current gold standard to reduce non-specific cellular uptake of drug delivery vehicles is by covalent attachment of poly(ethylene glycol) (PEG). It is thought that PEG can reduce protein… Expand
The effect of carboxydextran-coated superparamagnetic iron oxide nanoparticles on c-Jun N-terminal kinase-mediated apoptosis in human macrophages.
Superparamagnetic iron oxide nanoparticles are frequently used for cell labeling or as diagnostic contrast media, yet studies analyzing their effects on immune cells remain scarce. Here we… Expand
Uptake mechanism of oppositely charged fluorescent nanoparticles in HeLa cells.
- J. Dausend, A. Musyanovych, +4 authors V. Mailaender
- Chemistry, Medicine
- Macromolecular bioscience
- 8 December 2008
The endocytotic mechanisms involved in the uptake of charged polystyrene nanoparticles into HeLa cells were investigated. Uptake experiments were done in the presence or absence of drugs known to… Expand
Amino-functionalized polystyrene nanoparticles activate the NLRP3 inflammasome in human macrophages.
Specifically designed and functionalized nanoparticles hold great promise for biomedical applications. Yet, the applicability of nanoparticles is critically predetermined by their surface… Expand
Protein corona of nanoparticles: distinct proteins regulate the cellular uptake.
Understanding nanoparticle-protein interactions is a crucial issue in the development of targeted nanomaterial delivery. Besides unraveling the composition of the nanoparticle's protein coronas,… Expand
Uptake of functionalized, fluorescent-labeled polymeric particles in different cell lines and stem cells.
Labeling of cells with particles for in-vivo detection is interesting for various biomedical applications. The objective of this study was to evaluate the feasibility and efficiency labeling of cells… Expand
Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes.
Contrast agents based on dextran-coated superparamagnetic iron oxide nanoparticles (SPIO) are internalized by professional phagocytes such as hepatic Kupffer cells, yet their role in phagocyte… Expand
Preparation of Fluorescent Carboxyl and Amino Functionalized Polystyrene Particles by Miniemulsion Polymerization as Markers for Cells
Summary: A series of fluorescent polystyrene latex particles with carboxyl and amino functionalities on their surface were synthesized by the miniemulsion technique. The fluorescent dye… Expand
Interaction of nanoparticles with cells.
Nanoparticles and their interaction with human cells have been a focus of many groups during the past decade. We discuss and review here the progress in the field of understanding and harnessing the… Expand
Complementary analysis of the hard and soft protein corona: sample preparation critically effects corona composition.
Here we demonstrate how a complementary analysis of nanocapsule-protein interactions with and without application media allows gaining insights into the so called hard and soft protein corona. We… Expand