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Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP‐1 and NFκB transcription factors
TLDR
A role for curcumin as an adjunct to traditional chemotherapy and radiation in the treatment of brain cancer is supported, with effects correlated with reduced expression of bcl‐2 and IAP family members as well as DNA repair enzymes.
Neuroprotection by stem cell factor in rat cortical neurons involves AKT and NFκB
TLDR
A neuroprotective role for SCF and its tyrosine kinase receptor, c‐kit, is demonstrated against camptothecin‐induced apoptosis and glutamate excitotoxicity in rat cortical neurons, an effect that was mediated by Akt and ERK, as well as NFκB‐mediated gene transcription.
Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta.
TLDR
Northern-blot analysis of poly(A)+ RNA from several human tissues indicates a complex expression pattern differing across tissues, which indicates that the cloned taurine transporter is localized to human chromosome 3 p24-->p26.
Excitatory Amino Acids: Function and Significance in Reproduction and Neuroendocrine Regulation
TLDR
The steroid-induced LH surge in ovariectomized animals and the preovulatory surge of LH in cycling animals and in pregnant mare's serum gonadotropic-primed animals are blocked by the NMDA antagonist MK801 and the AMPA/kainate antagonist DNQX.
Role of Dickkopf-1, an Antagonist of the Wnt/β-Catenin Signaling Pathway, in Estrogen-Induced Neuroprotection and Attenuation of Tau Phosphorylation
TLDR
It is demonstrated that tauhyperphosphorylation is strongly induced after global cerebral ischemia, and that E2 inhibits tau hyperph phosphorylation by suppressing activation of the JNK/c-Jun/Dkk1 signaling pathway.
Rapid Estrogen Signaling in the Brain
TLDR
The growing evidence that rapid membrane-mediated effects of estrogen play an important physiological role in the neural actions of estrogen in the brain, including estrogen feedback control and modulation of homeostasis, regulation of synaptic plasticity/cognition, and estrogen-mediated neuroprotection is reviewed.
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