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NLRX1 is a regulator of mitochondrial antiviral immunity
The RIG-like helicase (RLH) family of intracellular receptors detect viral nucleic acid and signal through the mitochondrial antiviral signalling adaptor MAVS (also known as Cardif, VISA and IPS-1)… Expand
The effect of particle design on cellular internalization pathways
- Stephanie E. A. Gratton, P. A. Ropp, +4 authors J. Desimone
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 19 August 2008
The interaction of particles with cells is known to be strongly influenced by particle size, but little is known about the interdependent role that size, shape, and surface chemistry have on cellular… Expand
A pathogenic picornavirus acquires an envelope by hijacking cellular membranes
Animal viruses are broadly categorized structurally by the presence or absence of an envelope composed of a lipid-bilayer membrane, attributes that profoundly affect stability, transmission and… Expand
Comparative neurotoxicity of oxaliplatin, cisplatin, and ormaplatin in a Wistar rat model.
- J. Holmes, J. Stanko, +5 authors S. Chaney
- Chemistry, Medicine
- Toxicological sciences : an official journal of…
- 1 December 1998
Oxaliplatin (4 mg/kg), cisplatin (2 mg/kg with 20 mg/kg mannitol) and ormaplatin (2 mg/kg) were administered i.p. twice weekly for 4.5 weeks. Lactose injections (0.9%) were used as a control for… Expand
LIFE CYCLE OF THE HETEROTROPHIC DINOFLAGELLATE PFIESTERIA PISCICIDA (DINOPHYCEAE)1
The putatively toxic dinoflagellate Pfiesteria piscicida (Steidinger et Burkholder) has been reported to have an unusual life cycle for a free‐living marine dinoflagellate. As many as 24 life cycle… Expand
Macrophages sustain HIV replication in vivo independently of T cells.
- Jenna B Honeycutt, A. Wahl, +10 authors J. García
- Biology, Medicine
- The Journal of clinical investigation
- 1 April 2016
Macrophages have long been considered to contribute to HIV infection of the CNS; however, a recent study has contradicted this early work and suggests that myeloid cells are not an in vivo source of… Expand
Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation
Oxidative tissue injury often accompanies viral infection, yet there is little understanding of how it influences virus replication. We show that multiple hepatitis C virus (HCV) genotypes are… Expand
Host-derived intracellular immunization against mouse hepatitis virus infection.
Mouse hepatitis virus (MHV) utilizes the murine biliary glycoprotein receptor (BgpA) for entry into susceptible cells. The Bgp1 gene was transfected into a murine DBT cell clone that expressed little… Expand
Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR.
Molecular chaperones triage misfolded proteins via action as substrate selectors for quality control (QC) machines that fold or degrade clients. Herein, the endoplasmic reticulum (ER)-associated… Expand
Presence of urinary Haufen accurately predicts polyomavirus nephropathy.
- H. Singh, K. Andreoni, +4 authors V. Nickeleit
- Journal of the American Society of Nephrology…
- 1 February 2009
There are no accurate, noninvasive tests to diagnose BK polyomavirus nephropathy, a common infectious complication after renal transplantation. This study evaluated whether the qualitative detection… Expand