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Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol
TLDR
D disruption of the chemokine network interferes with motivational effects of alcohol, and null mutant mice with deletion of the Ccr2, Ccr5, Ccl2 or Ccl3 genes are studied.
Fetal Alcohol Exposure Alters Neurosteroid Modulation of Hippocampal N-Methyl-d-aspartate Receptors*
TLDR
It is determined that fetal alcohol exposure alters the actions of the neurosteroids pregnenolone sulfate and pregnanolone hemisuccinate, which potentiate NMDA receptor function, and in utero ethanol exposure did not affect theactions of neurosteroid that inhibit NMDA receptors.
Anxiolytic and antidepressant-like effects of Melissa officinalis (lemon balm) extract in rats: Influence of administration and gender
TLDR
The potential psychoactive properties of M. officinalis may provide a unique pharmacological alternative for certain psychiatric disorders; however, the efficacy appears to be dependent on both gender and administration length.
Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice
TLDR
The present results suggest that the extract produced dose-related antinociception in several models of chemical pain through mechanisms that involved cholinergic systems (i.e. through muscarinic and nicotinic acetylcholine receptors) and the L-arginine-nitric oxide pathway.
Antinociceptive effect of the aqueous extract obtained from roots of Physalis angulata L. on mice.
TLDR
It is demonstrated, for the first time, that the AE of Physalis angulata produce marked antinociception against the acetic acid-induced visceral pain and inflammatory pain responses induced by formalin in mice.
Dexamethasone Reverses the Ethanol-Induced Anxiolytic Effect in Rats
TLDR
The rapid blockade of ethanol induced anxiolysis by dexamethasone strengthens the suggestion that a nongenomic mechanism may underlie this response and the possible involvement of hippocampus in this response.
Interference of ethanol and methylmercury in the developing central nervous system.
TLDR
The results suggest that EtOH and/or MeHg intoxication during the developing CNS may be a risk for deficits related to locomotor impairment, anxiety, depression and neurocognitive functions.
Individual Housing From Rearing Modifies the Performance of Young Rats on the Elevated Plus-Maze Apparatus
TLDR
The results suggest that 60-day-old rats deprived of playfighting experience high basal anxiety levels and also that rearing conditions (isolated or grouped) are able to interact with both anxiolytic and anxiogenic effects of experimental drugs.
Ionotropic glutamate receptor subunit expression in the rat hippocampus: lack of an effect of a long-term ethanol exposure paradigm.
TLDR
The results indicate that maladaptive changes in the hippocampal expression levels of ionotropic glutamate receptor subunits do not always occur in ethanol-dependent rats, and other mechanisms must mediate the hyperexcitability state associated with ethanol withdrawal in these animals.
Inhibitory avoidance acquisition in adult rats exposed to a combination of ethanol and methylmercury during central nervous system development
TLDR
It is demonstrated that the exposure to both EtOH and MeHg has an impact on memory and panic-related behaviours, leading to the assertion that this association of toxicants should be studied more in detail to clarify the precise mechanisms of these pharmacological effects.
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