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Reactive Oxygen Species Mediate Caspase Activation and Apoptosis Induced by Lipoic Acid in Human Lung Epithelial Cancer Cells through Bcl-2 Down-Regulation
A novel pro-oxidant role of LA is indicated in apoptosis induction and its regulation by Bcl-2, which may be exploited for the treatment of cancer and related apoptosis disorders. Expand
Efficacy of Thai medicinal plant extracts against herpes simplex virus type 1 infection in vitro and in vivo.
Twenty Thai medicinal plant extracts were evaluated for anti-herpes simplex virus type 1 (HSV-1) activity and Aglaia odorata, Moringa oleifera, and Ventilago denticulata among the 11 were effective against thymidine kinase-deficient HSV- 1 and phosphonoacetate-resistant HSV -1 strains. Expand
The identities and anti-herpes simplex virus activity of Clinacanthus nutans and Clinacanthus siamensis.
The combination of macroscopic, microscopic and biomolecular method are able to authenticate these closely related plants and both of them have a potency to be an anti-HSV agent. Expand
Anti-herpes simplex virus (HSV-1) activity of oxyresveratrol derived from Thai medicinal plant: mechanism of action and therapeutic efficacy on cutaneous HSV-1 infection in mice.
The combination of oxyresveratrol and acyclovir (ACV) produced synergistic anti-HSV-1 effect, as characterized by the isobologram of plaque inhibition. Expand
New neolignans and a lignan from Miliusa fragrans, and their anti-herpetic and cytotoxic activities
Seven new neolignans and a new lignan were isolated from the leaves and the stems of Miliusa fragrans, along with nine known polyphenolic compounds. Their structures were established through analysisExpand
Synthesis and anti-herpes simplex viral activity of monoglycosyl diglycerides.
A study of the structure-activity relationships of the synthetic monoglycosyl diglycerides indicated that the fatty acyl moieties were critical for inhibitory action with higher activity displayed as the acyl groups became more olefinic in character. Expand
Topical cream-based oxyresveratrol in the treatment of cutaneous HSV-1 infection in mice.
It is demonstrated that topical administration of oxyresveratrol in novel cream vehicle reduced the concentration of oxyResver atrol to 10% and was suitable for cutaneous HSV infection. Expand
Microemulsion-Based Oxyresveratrol for Topical Treatment of Herpes Simplex Virus (HSV) Infection: Physicochemical Properties and Efficacy in Cutaneous HSV-1 Infection in Mice
Topical oxyresveratrol microemulsion at 20–30% w/w was suitable for cutaneous HSV-1 mouse infection and was significantly effective in delaying the development of skin lesions and protecting from death. Expand
Retained integrity of protein encapsulated in spray-dried chitosan microparticles.
In conclusion, chitosan microparticles for delivery of protein could be efficiently prepared by spray-drying technique and the encapsulated protein was capable of retaining its integrity after the preparation process. Expand
Hexane and dichloromethane extracts presented the anti-HSV-1 and HSV-2 activities with more than 50% inhibition of plaque formation at the concentration of 100 μg/ml and the cytotoxicity of the extracts to Vero cells was evaluated. Expand