• Publications
  • Influence
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
Protein lysine methyltransferases G9a and GLP modulate the transcriptional repression of a variety of genes via dimethylation of Lys9 on histone H3 (H3K9me2) as well as dimethylation of non-histoneExpand
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D-Serine Augments NMDA-NR2B Receptor-Dependent Hippocampal Long-Term Depression and Spatial Reversal Learning
The contributions of hippocampal long-term depression (LTD) to explicit learning and memory are poorly understood. Electrophysiological and behavioral studies examined the effects of modulating NMDAExpand
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Modulators of the glycine site on NMDA receptors, d-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia
RationaleSchizophrenia is characterized by disturbances in sensorimotor gating and attentional processes, which can be measured by prepulse inhibition (PPI) and latent inhibition (LI), respectively.Expand
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Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.
Abnormal N-methyl-d-aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. d-serine is an important NMDAR modulator, and to elucidate the role of theExpand
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The involvement of the NMDA receptor d-serine/glycine site in the pathophysiology and treatment of schizophrenia
  • V. Labrie, J. Roder
  • Biology, Medicine
  • Neuroscience & Biobehavioral Reviews
  • 1 February 2010
Hypofunction of the N-methyl-D-aspartate receptor (NMDAR) has been implicated in the pathophysiology of schizophrenia. The NMDAR contains a D-serine/glycine site on the NR1 subunit that may be aExpand
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Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis
We hypothesize that Parkinson's disease (PD) pathogenesis can be divided into three temporal phases. During the first phase, 'triggers', such as viral infections or environmental toxins, spark theExpand
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Epigenetics of major psychosis: progress, problems and perspectives.
Understanding the origins of normal and pathological behavior is one of the most exciting opportunities in contemporary biomedical research. There is increasing evidence that, in addition to DNAExpand
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Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice.
Activation of the N-methyl-D-aspartate receptor (NMDAR) glycine site has been shown to accelerate adaptive forms of learning that may benefit psychopathologies involving cognitive and perseverativeExpand
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Lactase non-persistence is directed by DNA variation-dependent epigenetic aging
The inability to digest lactose, due to lactase nonpersistence, is a common trait in adult mammals, except in certain human populations that exhibit lactase persistence. It is not known how theExpand
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Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia
RationaleSchizophrenic patients demonstrate prominent negative and cognitive symptoms that are poorly responsive to antipsychotic treatment. Abnormal glutamatergic neurotransmission may contribute toExpand
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