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Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis
Prenylated proteins contain a covalently linked cholesterol intermediate near their carboxyl-termini. Maturation of most prenylated proteins involves proteolytic removal of the last three aminoExpand
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Multigenic control of Listeria monocytogenes susceptibility in mice
We have used a novel quantitative trait locus model to study the genetics of survival of F2 progeny of susceptible BALB/cByJ and resistant C57BL/6ByJ mice that have been infected with ListeriaExpand
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The CaaX Proteases, Afc1p and Rce1p, Have Overlapping but Distinct Substrate Specificities
ABSTRACT Many proteins that contain a carboxyl-terminal CaaX sequence motif, including Ras and yeast a-factor, undergo a series of sequential posttranslational processing steps. Following the initialExpand
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Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis
Candida albicans is a ubiquitous opportunistic pathogen that is the most prevalent cause of hospital-acquired fungal infections. In mammalian hosts, C. albicans is engulfed by phagocytes that attackExpand
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Roles of prenyl protein proteases in maturation of Saccharomyces cerevisiae a-factor.
In eukaryotes small secreted peptides are often proteolytically cleaved from larger precursors. In Saccharomyces cerevisiae multiple proteolytic processing steps are required for production of matureExpand
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Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages
ABSTRACT Host cells use metabolic signaling through the LXRα nuclear receptor to defend against Listeria monocytogenes infection. 25-Hydroxycholesterol is a natural ligand of LXRs that is produced byExpand
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Isolation and DNA sequence of the STE14 gene encoding farnesyl cysteine: Carboxyl methyltransferase
We isolated a mutant defective in C‐terminal farnesyl cysteine:carboxyl methyltransferase activity from a screen for mutations causing a‐specific sterility. A genomic fragment was cloned from a yeastExpand
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Spt3 plays opposite roles in filamentous growth in Saccharomyces cerevisiae and Candida albicans and is required for C. albicans virulence.
Spt3 of Saccharomyces cerevisiae is required for the normal transcription of many genes in vivo. Past studies have shown that Spt3 is required for both mating and sporulation, two events thatExpand
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The Transcriptional Repressor BLIMP1 Curbs Host Defenses by Suppressing Expression of the Chemokine CCL8
The transcriptional repressor B lymphocyte–induced maturation protein 1 (BLIMP1) is a master regulator of B and T cell differentiation. To examine the role of BLIMP1 in innate immunity, we used aExpand
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Genetic Control of the Innate Immune Response to Borrelia hermsii Influences the Course of Relapsing Fever in Inbred Strains of Mice
ABSTRACT Host susceptibility to infection is controlled in large measure by the genetic makeup of the host. Spirochetes of the genus Borrelia include nearly 40 species of vector-borne spirochetesExpand
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