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Determination of rosuvastatin in rat plasma by HPLC: Validation and its application to pharmacokinetic studies.
A specific, accurate, precise and reproducible high-performance liquid chromatography (HPLC) method was developed for the estimation of rosuvastatin (RST), a novel, synthetic and potent HMG-CoAExpand
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Indications for single-dose activated charcoal administration in acute overdose
Purpose of reviewGastrointestinal decontamination in overdose patients remains a controversial problem in emergency medicine. There has been a significant decrease in the use of single-dose activatedExpand
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The effect of decontamination procedures on the pharmacodynamics of venlafaxine in overdose.
AIMS To investigate the relationship between decontamination procedures and seizure events caused by venlafaxine overdose and to estimate the time at which 90% of patients would have had their firstExpand
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Methods to Account for Inaccuracies in the Dosing History When Performing Population Pharmacokinetic Analysis
PurposeTo develop and assess methods to account for missing dose history (MDH).MethodsA simulation study was performed with different doses, dose times and formulations using NONMEM. Four methodsExpand
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The Effect of Decontamination Procedures on the Pharmacokinetics of Venlafaxine in Overdose
The aim of this work was to investigate the pharmacokinetics (PK) of venlafaxine in overdose and the effects of single‐dose activated charcoal (SDAC) and whole‐bowel irrigation (WBI), alone or inExpand
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Application of allometry principles for the prediction of human pharmacokinetic parameters for irbesartan, a AT1 receptor antagonist, from animal data
Allometric principles have been applied to scale and predict human pharmacokinetic parameters of irbesartan, an important AT1 receptor antagonist. The preclinical data gathered from rats, macaquesExpand
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Assessing the issue of instability due to Michael adduct formation in novel chemical entities possessing a carbon-carbon double bond during early drug development--applicability of common laboratory
The discovery of small-molecule novel chemical entities (NCEs) is often a complex play between appropriate structural requirements and optimization of the desired efficacy, safety and pharmacokineticExpand
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Design of Low Power 2-D Dct Architecture Using Reconfigurable Architecture
This Research paper includes designing a area efficient and low error Discrete Cosine Transform. This area efficient and low error DCT is obtained by using shifters and adders in place ofExpand
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Awareness and knowledge about bioterrorism among medical students at a University in Malaysia
The use of biological agents as weapons in warfare has been practiced since antiquity and is on the rise recently. In the event of an act of bioterrorism, health care professionals have to beExpand
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DATA HIDING USING BITSTREAM LEVEL THROUGH SELECTIVE EMBEDDING AND MODULATION
Hiding the data in the Video is still an important research issue,but the problem with the traditional mechanisms it leads to the distortion and error prone. However, most of the video data hidingExpand
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