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A Developmental Shift from GABAergic to Glycinergic Transmission in the Central Auditory System
GABAergic and glycinergic circuits are found throughout the auditory brainstem, and it is generally assumed that transmitter phenotype is established early in development. The present study documentsExpand
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Hearing Loss Raises Excitability in the Auditory Cortex
Developmental hearing impairments compromise sound discrimination, speech acquisition, and cognitive function; however, the adjustments of functional properties in the primary auditory cortex (A1)Expand
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Enhancement of Signal-to-Noise Ratio and Phase Locking for Small Inputs by a Low-Threshold Outward Current in Auditory Neurons
Neurons possess multiple voltage-dependent conductances specific for their function. To investigate how low-threshold outward currents improve the detection of small signals in a noisy background, weExpand
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Age-dependent effect of hearing loss on cortical inhibitory synapse function.
The developmental plasticity of excitatory synapses is well established, particularly as a function of age. If similar principles apply to inhibitory synapses, then we would expect manipulationsExpand
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Asymmetric Excitatory Synaptic Dynamics Underlie Interaural Time Difference Processing in the Auditory System
In order to localize sounds in the environment, the auditory system detects and encodes differences in signals between each ear. The exquisite sensitivity of auditory brain stem neurons to theExpand
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Hearing loss differentially affects thalamic drive to two cortical interneuron subtypes.
Sensory deprivation, such as developmental hearing loss, leads to an adjustment of synaptic and membrane properties throughout the central nervous system. These changes are thought to compensate forExpand
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Commissural and lemniscal synaptic input to the gerbil inferior colliculus.
The central nucleus of the inferior colliculus (ICC) receives direct inputs, bilaterally, from all auditory brain stem nuclear groups. To evaluate the contribution made to gerbil ICC neuronExpand
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Conductive Hearing Loss Disrupts Synaptic and Spike Adaptation in Developing Auditory Cortex
Although sensorineural hearing loss (SNHL) is known to compromise central auditory structure and function, the impact of milder forms of hearing loss on cellular neurophysiology remains mostlyExpand
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Presynaptic GABAB Receptors Regulate Experience-Dependent Development of Inhibitory Short-Term Plasticity
Short-term changes in synaptic gain support information processing throughout the CNS, yet we know little about the developmental regulation of such plasticity. Here we report that auditoryExpand
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Developmental hearing loss disrupts synaptic inhibition: implications for auditory processing.
Hearing loss during development leads to central deficits that persist even after the restoration of peripheral function. One key class of deficits is due to changes in central inhibitory synapses,Expand
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