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Monoclonal antibody--specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet-reactive antibodies.
A new assay is described that takes advantage of monoclonal antibodies against major platelet membrane constituents (glycoproteins IIb/IIIa and Ib and HLA class I molecule) to investigate selectively platelet reactive antibodies against epitopes on different glycoprotein.
Laboratory diagnosis of heparin‐associated thrombocytopenia and comparison of platelet aggregation test, heparin‐induced platelet activation test, and platelet factor 4/heparin enzyme‐linked
BACKGROUND: As clinical diagnosis of heparin‐associated thrombocytopenia (HAT) is often difficult, confirmation by sensitive laboratory assays is desirable.
Nomenclature of human platelet antigens
This paper presents a systematic literature review and meta-analyses of Platelet Transfusion Medicine and its Applications to Plasma Science, showing clear trends in high-security blood transfusions and in particular the use of transfusions to treat high-risk patients with high blood pressure.
A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia.
Using sera of 34 patients with clinically suspected HAT, the HIPA assay is found to be as sensitive as the SRA and superior to PAA and may be a useful tool for differential diagnosis and therapy in patients with HAT.
Immune Thrombocytopenia - Current Diagnostics and Therapy: Recommendations of a Joint Working Group of DGHO, ÖGHO, SGH, GPOH, and DGTI
This paper presents a meta-analyses of the Hematology and Hemostaseology Unit at the Ludwig Maximilian University of Munich (Munich) which shows clear trends in prognosis for oncology- Hematology-Hemostase disorder in young people aged between the ages of 18 and 25.
Platelet alloantibodies in transfused patients
Patients receiving cellular blood components may form HLA antibodies and platelet‐specific alloantibodies, and these antibodies and allo Antibodies may be related to HLA or platelet-specific antibodies.
The MAIPA assay and its applications in immunohaematology
  • V. Kiefel
  • Biology, Medicine
    Transfusion medicine
  • 1 September 1992
The monoclonal antibody immobilization of platelet antigens (MAIPA) assay has proved to be a reliable and useful tool in platelet immunology and has successfully been applied to characterize antibodies against lymphocytes, endothelial cells and granulocytes.
Analysis of granulocyte‐reactive antibodies using an immunoassay based upon monoclonal‐antibody‐specific immobilization of granulocyte antigens
A glycoprotein‐specific enzyme immunoassay for platelet antibodies was adapted for the use of granulocytes as target cells to allow identification of different granulocyte‐reactive antibodies present in the same sample without the need for complicated absorption studies.
Autoantibodies against platelet glycoprotein Ib/IX: a frequent finding in autoimmune thrombocytopenic purpura
The observation that in 23 (28%) of these sera the antigenic determinants could not be assigned to the glycoproteins under investigation suggests that platelet autoantibodies may react with other GPs or other membrane constituents, e.g. glycolipids.