Biomedical applications of hydrogels: A review of patents and commercial products
- E. Caló, V. Khutoryanskiy
- Biology
- 1 April 2015
Advances in mucoadhesion and mucoadhesive polymers.
- V. Khutoryanskiy
- Medicine, BiologyMacromolecular Bioscience
- 14 June 2011
The most common methods to evaluate mucoadhesive properties of various dosage forms are described, and the main classes of mucoADhesives are discussed, which are typical for hydrophilic polymers possessing charged groups and/or non-ionic functional groups capable of forming hydrogen bonds with mucosal surfaces.
Microencapsulation of probiotics for gastrointestinal delivery.
- M. Cook, G. Tzortzis, D. Charalampopoulos, V. Khutoryanskiy
- BiologyJournal of Controlled Release
- 20 August 2012
Production and evaluation of dry alginate-chitosan microcapsules as an enteric delivery vehicle for probiotic bacteria.
- M. Cook, G. Tzortzis, D. Charalampopoulos, V. Khutoryanskiy
- EngineeringBiomacromolecules
- 25 May 2011
It was shown that chitosan stabilizes the alginate microcapsules at pHs above 3, extending the stability of the capsules under these conditions and increasing the survival of B. breve in simulated gastric fluid as well as prolong its release upon exposure to intestinal pH.
Why is chitosan mucoadhesive?
- Ioannis A Sogias, Adrian C Williams, V. Khutoryanskiy
- BiologyBiomacromolecules
- 10 June 2008
It is demonstrated that electrostatic attraction forces between chitosan and gastric mucin can be suppressed in the presence of 0.2 mol/L sodium chloride; however, this does not prevent the aggregation of mucin particles in the absence of this biopolymer.
Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems
- Twana Mohammed M Ways, W. Lau, V. Khutoryanskiy
- Biology, ChemistryPolymers
- 1 March 2018
This review has particularly focused on the effect of chemical derivatization on the mucoadhesive properties of chitosan, and other important properties including water-solubility, stability, controlled release, permeation enhancing effect, and in vivo performance are described.
In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery.
- Kosai Al Khateb, Elvira K. Ozhmukhametova, V. Khutoryanskiy
- EngineeringInternational journal of pharmaceutics
- 11 April 2016
Exploring the Factors Affecting the Solubility of Chitosan in Water
- Ioannis A Sogias, V. Khutoryanskiy, Adrian C Williams
- Chemistry
- 15 February 2010
We explore the role of crystallinity and inter- or intramolecular forces in chitosan for its solubility in water and demonstrate the expansion of its solubility to a wider pH range. Due to its…
Chitosan coated alginate beads for the survival of microencapsulated Lactobacillus plantarum in pomegranate juice.
- S. Nualkaekul, Dominique Lenton, M. Cook, V. Khutoryanskiy, D. Charalampopoulos
- Chemistry, MedicineCarbohydrate Polymers
- 15 October 2012
Penetration Enhancers in Ocular Drug Delivery
- Roman V Moiseev, Peter W J Morrison, F. Steele, V. Khutoryanskiy
- Biology, MedicinePharmaceutics
- 1 July 2019
An overview of anatomical and physiological features of the eye is provided and some common ophthalmological conditions and permeability of ocular membranes are discussed.
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