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Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations
Summary Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising source for cell replacementExpand
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Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
Hyperphosphorylated forms of the microtubule-associated protein (MAP) tau accumulate in Alzheimer's disease and related tauopathies and are thought to have an important role in neurodegeneration.Expand
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Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders
How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functionalExpand
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TOR-Mediated Cell-Cycle Activation Causes Neurodegeneration in a Drosophila Tauopathy Model
BACKGROUND Previous studies have demonstrated reexpression of cell-cycle markers within postmitotic neurons in neurodegenerative tauopathies, including Alzheimer's disease (AD). However, the criticalExpand
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Enhancing encoding of a motor memory in the primary motor cortex by cortical stimulation.
Motor training results in encoding of motor memories, a form of use-dependent plasticity. Here we tested the hypothesis that transcranial magnetic stimulation (TMS) synchronously applied to a motorExpand
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β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
Elucidating the risk of Parkinson's disease High expression of the α-synuclein gene (SNCA) is a risk factor for Parkinson's disease (PD), but certain drugs may mitigate this risk. Mittal et al. ran aExpand
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Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons
From Yeast to Therapeutic? Yeast has shown some promise as a model system to generate lead compounds that could have therapeutic potential for the cellular problems associated with neurodegenerativeExpand
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Yeast Reveal a “Druggable” Rsp5/Nedd4 Network that Ameliorates α-Synuclein Toxicity in Neurons
From Yeast to Therapeutic? Yeast has shown some promise as a model system to generate lead compounds that could have therapeutic potential for the cellular problems associated with neurodegenerativeExpand
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Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo
Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differingExpand
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Accelerated Accumulation of Misfolded Prion Protein and Spongiform Degeneration in a Drosophila Model of Gerstmann–Sträussler–Scheinker Syndrome
Prion diseases are CNS disorders that can occur in sporadic, infectious, and inherited forms. Although all forms of prion disease are associated with the accumulation of pathogenic conformers of theExpand
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