Serotonin and epilepsy
- G. Bagdy, V. Kecskeméti, P. Riba, R. Jakus
- Biology, PsychologyJournal of Neurochemistry
- 1 February 2007
Imaging data and analysis of resected tissue of epileptic patients, and studies in animal models all provide evidence that endogenous 5‐HT, the activity of its receptors, and pharmaceuticals with serotonin agonist and/or antagonist properties play a significant role in the pathogenesis of epilepsies.
Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?
It is suggested that the new generation of antidepressants and antipsychotics introduced during the past decade also have clinically important cardiac as well as vascular effects.
Diabetes mellitus attenuates the repolarization reserve in mammalian heart.
Increased myogenic tone in skeletal muscle arterioles of diabetic rats. Possible role of increased activity of smooth muscle Ca2+ channels and protein kinase C.
Trends in the development of new antidepressants. Is there a light at the end of the tunnel?
The goal of this review is to give a brief overview of the major advances from monoamine-based treatment strategies, and particularly focus on the new emerging approaches in the treatment of depression.
Inhibition of voltage-gated calcium channels by fluoxetine in rat hippocampal pyramidal cells
Serotonin reuptake inhibitor, fluoxetine, dilates isolated skeletal muscle arterioles. Possible role of altered Ca2+ sensitivity
- P. Pacher, Z. Ungvari, V. Kecskeméti, A. Koller
- Biology, MedicineBritish Journal of Pharmacology
- 1 June 1999
It is found that fluoxetine elicits substantial dilations of isolated skeletal muscle arterioles, a response which is not mediated by 4‐AP‐ and ATP‐sensitive K+ channels or endothelium‐derived dilator factors, and this suggests that fluxetine may inhibit Ca2+ channel(s) or interfere with the signal transduction by Ca1+ in the vascular smooth muscle cells.
Speculations on difference between tricyclic and selective serotonin reuptake inhibitor antidepressants on their cardiac effects. Is there any?
- P. Pacher, Z. Ungvari, P. Nanasi, S. Furst, V. Kecskeméti
- Medicine, PsychologyCurrent Medicinal Chemistry
- 1 June 1999
The results suggest that fluoxetine and citalopram may have antiarrhythmic (class I + IV type), as well as proarrhythmmic properties (due to impairment of atrioventricular or intraventricular conduction and shortening of repolarization) and in depressed patients having also severe cardiac disorders, ECG control may be suggested.
Electrophysiological changes in rat ventricular and atrial myocardium at different stages of experimental diabetes.
- P. Pacher, Z. Ungvari, P. Nanasi, V. Kecskeméti
- Medicine, BiologyActa Physiologica Scandinavica
- 1 May 1999
The results indicate that development of diabetic alterations are not fully identical in atrial and ventricular myocardium of the rat, probably owing to differences in density and kinetics of ionic currents responsible for atrialand ventricular action potentials.
Fluoxetine dilates isolated small cerebral arteries of rats and attenuates constrictions to serotonin, norepinephrine, and a voltage-dependent Ca(2+) channel opener.
The finding that fluoxetine inhibits constrictor responses to Ca(2+) channel opener, as well as serotonin and norepinephrine, suggests that fluxetine interferes with the Ca( 2+) signaling mechanisms in the vascular smooth muscle.