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CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin.
TLDR
It is concluded that CD151 is essential for the proper assembly of the glomerular and tubular basement membrane in kidney, has functional significance in the skin, is probably a component of the inner ear, and could play a role in erythropoiesis.
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Two MER2‐negative individuals with the same novel CD151 mutation and evidence for clinical significance of anti‐MER2
TLDR
Two new examples of alloanti‐MER2 are reported, in women of Pakistani and Turkish origin, one of whom showed signs of a hemolytic transfusion reaction (HTR) after transfusion of 3 units of red cells (RBCs).
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Different inactivating mutations in the LU genes of three individuals with the Lutheran‐null phenotype
TLDR
The null phenotype of the Lutheran blood group system, Lunull or Lu(a–b–), is characterized by the lack of all Lutheran system antigens and appears to result from homozygosity for an inactive LU gene.
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Three uncommon KEL alleles in one family with unusual Kell phenotypes explain a 35‐year old conundrum
TLDR
Molecular analysis of three uncommon KEL alleles elucidated the obscure pattern of inheritance of Kell antigens in one family.
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Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype
TLDR
It is shown that EMP3, a purported tumour suppressor in various solid tumours, is expressed in erythroid cells and found to associate with, and stabilise, CD44 in the plasma membrane, establishing MAM as a new blood group system and demonstrating the role of EMP3 in ERYthropoiesis through its interaction with the signalling molecule CD44.
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New mutations in C1GALT1C1 in individuals with Tn positive phenotype
Tn polyagglutination results from inactivating mutations in C1GALT1C1, an X‐borne gene encoding a core 1 β3‐galactosyltransferase‐specific molecular chaperone (cosmc) required for the functioning of…
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A large deletion spanning XG and GYG2 constitutes a genetic basis of the Xgnull phenotype, underlying anti‐Xga production
TLDR
The PBDX/XG gene encoding the Xga blood group antigen was described in 1994, but the genetic determinant of XG expression on RBCs was reported only in 2018, and the molecular basis of the Xg(a−) phenotype in people producing anti‐Xga was sought.
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P40
A Novel Variant in the Ok Blood Group System
TLDR
Oka is located on the immunoglobulin superfamily glycoprotein CD147, also known as M6 leukocyte activation antigen, basigin (BSG) or extracellular matrix metalloproteinase inducer (EMMPRIN).
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CROK (CROM19): A new high‐prevalence antigen in the Cromer blood group system
TLDR
This poster presents a probabilistic procedure to characterize the response of the immune system to various types of deposits in the blood of animals and shows clear signs of rejection.
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P39
The Second Example of LU:‐4: a Serological and Molecular Study
TLDR
Lutheran antigens are carried on two red cell membrane glycoproteins, Lu‐glycoprotein and epithelial cancer antigen and are encoded by a single gene LU located on chromosome 19q13.2 and organised into 15 exons.
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