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Proton-coupled electron transfer in cytochrome oxidase.
3.3. Electron Tunneling between the Heme Groups 7068 4. Catalytic Cycle and States of the Binuclear Center 7069 4.1. O2 Binding and Bond Splitting 7069 4.2. Intermediate States of the BinuclearExpand
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Glutamic acid 242 is a valve in the proton pump of cytochrome c oxidase
Aerobic life is based on a molecular machinery that utilizes oxygen as a terminal electron sink. The membrane-bound cytochrome c oxidase (CcO) catalyzes the reduction of oxygen to water inExpand
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  • Open Access
New perspectives on proton pumping in cellular respiration.
Mar̊ten Wikström,*,† Vivek Sharma,‡ Ville R. I. Kaila, Jonathan P. Hosler, and Gerhard Hummer †Institute of Biotechnology, University of Helsinki, Biocenter 3 (Viikinkaari 1), PB 65, Helsinki 00014,Expand
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Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90
Significance Hsp90 is a molecular chaperone involved in the activation of numerous client proteins, including 60% of the human kinases. Previous studies on the Hsp90–kinase interaction were limitedExpand
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Watching a signaling protein function in real time via 100-ps time-resolved Laue crystallography
To understand how signaling proteins function, it is crucial to know the time-ordered sequence of events that lead to the signaling state. We recently developed on the BioCARS 14-IDB beamline at theExpand
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  • Open Access
The identity of the transient proton loading site of the proton-pumping mechanism of cytochrome c oxidase.
Cellular respiration is driven by cytochrome c oxidase (CcO), which reduces oxygen to water and couples the released energy to proton pumping across the mitochondrial or bacterial membrane. ProtonExpand
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Human adipose tissue extract induces angiogenesis and adipogenesis in vitro.
The induction of adequate vascularization, a major challenge in tissue engineering, has been tried with numerous methods but with unsatisfactory results. Adipose tissue, an active endocrine organExpand
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Dynamic water networks in cytochrome cbb3 oxidase.
Heme-copper oxidases (HCOs) are terminal electron acceptors in aerobic respiration. They catalyze the reduction of molecular oxygen to water with concurrent pumping of protons across theExpand
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Mechanism and energetics by which glutamic acid 242 prevents leaks in cytochrome c oxidase.
Cytochrome c oxidase (CcO) is the terminal enzyme of aerobic respiration. The energy released from the reduction of molecular oxygen to water is used to pump protons across the mitochondrial orExpand
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Charge parameterization of the metal centers in cytochrome c oxidase
Reliable atomic point charges are of key importance for a correct description of the electrostatic interactions when performing classical, force field based simulations. Here, we present a systematicExpand
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