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Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice.
TLDR
It is demonstrated that pharyngeal aspiration of SWCNT elicited unusual pulmonary effects in C57BL/6 mice that combined a robust but acute inflammation with early onset yet progressive fibrosis and granulomas and caused a significantly weaker pulmonary inflammation and damage. Expand
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
TLDR
Insight is provided into the role of reactive oxygen species in triggering the cell-death pathway and an early role for cytochrome c before caspase activation is described. Expand
Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis.
TLDR
SWCNT inhalation was more effective than aspiration in causing inflammatory response, oxidative stress, collagen deposition, and fibrosis as well as mutations of K-ras gene locus in the lung of C57BL/6 mice. Expand
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
TLDR
The mechanisms underlying ferroptosis are reviewed, connections to other areas of biology and medicine are highlighted, and tools and guidelines for studying this emerging form of regulated cell death are recommended. Expand
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
TLDR
Red redistribution of cardiolipin serves as an ‘eat-me’ signal for the elimination of damaged mitochondria from neuronal cells as well as the engulfment of mitochondria by the autophagic system. Expand
Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron.
TLDR
Catalase was able to partially protect macrophages against SWCNT induced elevation of biomarkers of oxidative stress (enhancement of lipid peroxidation and GSH depletion) and the presence of iron in SWC NT may be important in determining redox-dependent responses of macrophage. Expand
Lipid accumulation and dendritic cell dysfunction in cancer
TLDR
It is reported that a substantial proportion of DCs in tumor-bearing mice and people with cancer have high amounts of triglycerides as compared with DCs from tumor-free mice and healthy individuals, and Pharmacological normalization of lipid abundance in DCs with an inhibitor of acetyl-CoA carboxylase restored the functional activity ofDCs and substantially enhanced the effects of cancer vaccines. Expand
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
TLDR
It is demonstrated that ferroptosis is a pervasive and dynamic form of cell death, which, when impeded, promises substantial cytoprotection. Expand
Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation.
TLDR
It is shown that hypochlorite and reactive radical intermediates of the human neutrophil enzyme myeloperoxidase catalyse the biodegradation of single-walled carbon nanotubes in vitro, in neutrophils and to a lesser degree in macrophages. Expand
Single-walled Carbon Nanotubes: Geno- and Cytotoxic Effects in Lung Fibroblast V79 Cells
TLDR
The genotoxic effects of nanoparticles were examined using three different test systems: the comet assay and micronucleus (MN) test in a lung fibroblast (V79) cell line, and the Salmonella gene mutation assay in strains YG1024/YG1029. Expand
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