• Publications
  • Influence
Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating akt and p38 mAPK
Curcumin, a major active component of turmeric, is known to induce apoptosis in several types of cancer cells, but little is known about its activity in chemoresistant cells. Hence, the aim of theExpand
  • 233
  • 12
Oxidative stress in cardiovascular disease.
Over the last two decades, it has become increasingly clear that reactive oxygen species (ROS), including free radicals are involved in cardiovascular disease. In recent years, there has been aExpand
  • 216
  • 7
  • PDF
Protective effect of Spirulina against doxorubicin‐induced cardiotoxicity
The generation of reactive oxygen species and mitochondrial dysfunction has been implicated in doxorubicin (DOX)‐induced cardiotoxicity. The aim of the present study was to determine whetherExpand
  • 140
  • 6
C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling.
We previously showed that C-phycocyanin (PC), an antioxidant biliprotein pigment of Spirulina platensis (a blue-green alga), effectively inhibited doxorubicin-induced oxidative stress and apoptosisExpand
  • 81
  • 5
  • PDF
Hypoxic reperfusion of the ischemic heart and oxygen radical generation.
Postischemic myocardial contractile dysfunction is in part mediated by the burst of reactive oxygen species (ROS), which occurs with the reintroduction of oxygen. We hypothesized that tissue oxygenExpand
  • 89
  • 4
  • PDF
Endothelial Dysfunction in Type 2 Diabetes Mellitus
Endothelial dysfunction is an imbalance in the production of vasodilator factors and when this balance is disrupted, it predisposes the vasculature towards pro-thrombotic and pro-atherogenic effects.Expand
  • 62
  • 4
FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways.
Phagocytosis of IgG-coated particles via FcgammaR is accompanied by the generation of superoxide and inflammatory cytokines, which can cause collateral tissue damage in the absence of regulation.Expand
  • 40
  • 4
Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer
In view of growing body of evidence substantiating the role of aberrations in one-carbon metabolism in the pathophysiology of breast cancer and lack of studies on gene–gene interactions, weExpand
  • 54
  • 3
Spirulina attenuates cyclosporine‐induced nephrotoxicity in rats
Cyclosporine (CsA) causes a dose‐related decrease in renal function in experimental animals and humans. The generation of reactive oxygen species (ROS) has been implicated in CsA‐inducedExpand
  • 68
  • 3
Association of aberrations in one‐carbon metabolism with molecular phenotype and grade of breast cancer
We have earlier demonstrated the role of aberrant one‐carbon metabolism in the etiology of breast cancer. In the current study, we examine the clinical utility of these factors in predicting theExpand
  • 30
  • 3