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Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans.
The ultimate goal is not only to describe detailed gene expression profiles, but also to gain a greater understanding of the organization of gene regulatory networks and to determine how they control cell function during development and differentiation in C. elegans.
TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone.
Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance
Evidence is presented that Caenorhabditis elegans MKS‐5 may not be a simple structural scaffold for anchoring > 10 different proteins at the TZ, but instead, functions as an assembly factor and a new model for Mks5/Rpgrip1L in TZ assembly and function that is essential for establishing the ciliary signalling compartment is suggested.
MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone
These findings expand the repertoire of MKS module-associated proteins—including the previously uncharacterised mammalian Tmem80—and suggest an MKS-5 and CEP-290-dependent assembly pathway for building a functional TZ.
Gates for soluble and membrane proteins, and two trafficking systems (IFT and LIFT), establish a dynamic ciliary signaling compartment.
Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport
These findings present a new approach for identifying ciliary proteins, and unveil RAB28, a GTPase most closely related to the BBS protein RABL4/IFT27, as an IFT-associated cargo with BBSome-dependent cell autonomous and non-autonomous functions at the ciliary base.
Localization of a Guanylyl Cyclase to Chemosensory Cilia Requires the Novel Ciliary MYND Domain Protein DAF-25
A novel ciliary protein that plays an important role in cGMP signaling by localizing a guanylyl cyclase to the sensory organelle is discovered by demonstrating that Daf-25 is required for proper DAF-11 ciliary localization.
Targets of DAF-16 involved in Caenorhabditis elegans adult longevity and dauer formation
CiliaCarta: An integrated and validated compendium of ciliary genes
It is shown that OSCP1, which has previously been implicated in two distinct non-ciliary processes, causes ciliogenic and ciliopathy-associated tissue phenotypes when depleted in zebrafish.
CiliaCarta: an integrated and validated compendium of ciliary genes
The cilium is an essential organelle at the surface of most mammalian cells whose dysfunction causes a wide range of genetic diseases collectively called ciliopathies, and genomic, proteomic, transcriptomic and evolutionary data are analyzed and systematically integrated into a predictive score for ciliary function.