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Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans.
TLDR
The ultimate goal is not only to describe detailed gene expression profiles, but also to gain a greater understanding of the organization of gene regulatory networks and to determine how they control cell function during development and differentiation in C. elegans.
Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance
TLDR
Evidence is presented that Caenorhabditis elegans MKS‐5 may not be a simple structural scaffold for anchoring > 10 different proteins at the TZ, but instead, functions as an assembly factor and a new model for Mks5/Rpgrip1L in TZ assembly and function that is essential for establishing the ciliary signalling compartment is suggested.
MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone
TLDR
These findings expand the repertoire of MKS module-associated proteins—including the previously uncharacterised mammalian Tmem80—and suggest an MKS-5 and CEP-290-dependent assembly pathway for building a functional TZ.
Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport
TLDR
These findings present a new approach for identifying ciliary proteins, and unveil RAB28, a GTPase most closely related to the BBS protein RABL4/IFT27, as an IFT-associated cargo with BBSome-dependent cell autonomous and non-autonomous functions at the ciliary base.
Localization of a Guanylyl Cyclase to Chemosensory Cilia Requires the Novel Ciliary MYND Domain Protein DAF-25
TLDR
A novel ciliary protein that plays an important role in cGMP signaling by localizing a guanylyl cyclase to the sensory organelle is discovered by demonstrating that Daf-25 is required for proper DAF-11 ciliary localization.
CiliaCarta: An integrated and validated compendium of ciliary genes
TLDR
It is shown that OSCP1, which has previously been implicated in two distinct non-ciliary processes, causes ciliogenic and ciliopathy-associated tissue phenotypes when depleted in zebrafish.
CiliaCarta: an integrated and validated compendium of ciliary genes
TLDR
The cilium is an essential organelle at the surface of most mammalian cells whose dysfunction causes a wide range of genetic diseases collectively called ciliopathies, and genomic, proteomic, transcriptomic and evolutionary data are analyzed and systematically integrated into a predictive score for ciliary function.
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