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Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts
TLDR
This work shows that ceramide-enriched membrane platforms are central to the host defense against this potentially lethal pathogen P. aeruginosa.
View on Springer
Ceramide-Rich Membrane Rafts Mediate CD40 Clustering1
TLDR
It is shown that acid sphingomyelinase (ASM) is essential for the clustering of CD40, which seems to be a prerequisite for cellular activation via CD40.
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Targeting apoptosis pathways by Celecoxib in cancer.
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Long-term follow-up and outcome of 39 patients with chronic granulomatous disease.
TLDR
Infections with Aspergillus species have become the major cause of infectious complications and death in patients withCGD and prophylactic and therapeutic measures are needed to further increase life expectancy and quality for patients with CGD.
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Stimulation of erythrocyte ceramide formation by platelet-activating factor
TLDR
The study demonstrates that platelet-activating factor (PAF) is released from erythrocytes upon hyperosmotic cell shrinkage and leads to the activation of scramblase with subsequent phosphatidylserine exposure.
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Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic Pathway
TLDR
Interestingly, DHA increased the cytotoxic action of ionizing radiation and of the death receptor agonist tumor necrosis factor-related apoptosis-inducing ligand in Jurkat cells, suggesting a potential benefit of DHA in combined treatment strategies.
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Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways.
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Unraveling the Function of the Rhodospirillum rubrum Activator of Polyhydroxybutyrate (PHB) Degradation: the Activator Is a PHB-Granule-Bound Protein (Phasin)
TLDR
Evidence is obtained that Mms16 of Magnetospirillum gryphiswaldense can functionally replace ApdA in R. rubrum, a PHB-bound, phasin-like protein in magnetotactic bacteria, and no GTPase activity ofApdA could be demonstrated.
View on ASMUSA
Celecoxib activates a novel mitochondrial apoptosis signaling pathway
TLDR
Celecoxib induces apoptosis via a novel apoptosome‐dependent but Bcl‐2‐independent mitochondrial pathway through the induction of apoptosis upon treatment with Celecoxib was tested in Jurkat T‐ and BJAB B‐lymphoma cell lines with defects in either pathway.
View on Wiley
Epac inhibits migration and proliferation of human prostate carcinoma cells
TLDR
In human prostate carcinoma cells, Epac inhibits proliferative and migratory responses likely because of inhibition of MAP kinase and RhoA signalling pathways, which might represent an attractive therapeutic target in the treatment of prostate cancer.
View on Nature
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