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Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts
TLDR
This work shows that ceramide-enriched membrane platforms are central to the host defense against this potentially lethal pathogen P. aeruginosa. Expand
Long-term follow-up and outcome of 39 patients with chronic granulomatous disease.
TLDR
Infections with Aspergillus species have become the major cause of infectious complications and death in patients withCGD and prophylactic and therapeutic measures are needed to further increase life expectancy and quality for patients with CGD. Expand
Ceramide-Rich Membrane Rafts Mediate CD40 Clustering1
TLDR
It is shown that acid sphingomyelinase (ASM) is essential for the clustering of CD40, which seems to be a prerequisite for cellular activation via CD40. Expand
Targeting apoptosis pathways by Celecoxib in cancer.
TLDR
The use of Celecoxib may be of specific value for the treatment of apoptosis-resistant tumors with overexpression of Bcl-2, Mcl-1, or survivin as single drug or in combination with radiotherapy, chemotherapy, or targeted pro-apoptotic drugs that are inhibited by survivin, BCl-2 or MCl-1. Expand
Stimulation of erythrocyte ceramide formation by platelet-activating factor
TLDR
The study demonstrates that platelet-activating factor (PAF) is released from erythrocytes upon hyperosmotic cell shrinkage and leads to the activation of scramblase with subsequent phosphatidylserine exposure. Expand
Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic Pathway
TLDR
Interestingly, DHA increased the cytotoxic action of ionizing radiation and of the death receptor agonist tumor necrosis factor-related apoptosis-inducing ligand in Jurkat cells, suggesting a potential benefit of DHA in combined treatment strategies. Expand
Celecoxib activates a novel mitochondrial apoptosis signaling pathway
TLDR
Celecoxib induces apoptosis via a novel apoptosome‐dependent but Bcl‐2‐independent mitochondrial pathway through the induction of apoptosis upon treatment with Celecoxib was tested in Jurkat T‐ and BJAB B‐lymphoma cell lines with defects in either pathway. Expand
Epac inhibits migration and proliferation of human prostate carcinoma cells
TLDR
In human prostate carcinoma cells, Epac inhibits proliferative and migratory responses likely because of inhibition of MAP kinase and RhoA signalling pathways, which might represent an attractive therapeutic target in the treatment of prostate cancer. Expand
High activity of acid sphingomyelinase in major depression
TLDR
It is demonstrated that the antidepressants imipramine and amitriptyline induce a long-term reduction of the activity of A-SMase in cultured cells. Expand
Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways.
TLDR
ZM-induced apoptosis depends not only on polyploidization, but also on the intracellular apoptotic signaling, suggesting apoptosis may be a secondary event following polyploidsization in HCT-116 cells. Expand
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