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A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis
TLDR
A diarylquinoline, R207910, is identified that potently inhibits both drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro and mutants selected in vitro suggest that the drug targets the proton pump of adenosine triphosphate (ATP) synthase. Expand
Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns.
TLDR
Before 1985 at the Pitié-Salpêtrière Hospital in Paris, resistance to cefotaxime in clinical isolates of Enterobacteriaceae involved only species producing inducible class 1 beta-lactamase; between November 1985 and April 1987, however, 62 isolates showed decreased susceptibility to cffotaximes, and these enzymes were designated EBS-Bla. Expand
Phenotypic detection of extended-spectrum beta-lactamase production in Enterobacteriaceae: review and bench guide.
TLDR
Several phenotypic detection tests, based on the synergy between a third-generation cephalosporin and clavulanate, have been designed: the double-disk synergy test (DDST), ESBL Etests, and the combination disk method. Expand
Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts.
TLDR
A consultation of experts from 31 countries set out to identify the gaps in diagnostic and response capacity, to index the magnitude of carbapenem-non-susceptibility across Europe using a novel five-level staging system, and to provide elements of a strategy to combat this public health issue in a concerted manner. Expand
The changing epidemiology of bacteraemias in Europe: trends from the European Antimicrobial Resistance Surveillance System.
TLDR
The data suggest that the burden of bacterial bloodstream infection has been increasing for all species during EARSS surveillance, and it appears that infections with resistant clones add to rather than replace infections caused by susceptible bacteria. Expand
Assessment of Clarithromycin Susceptibility in Strains Belonging to the Mycobacterium abscessus Group by erm(41) and rrl Sequencing
TLDR
Clarithromycin-resistant strains, including the six rrl mutants, were more often isolated in cystic fibrosis patients, but this was not significantly associated with a previous treatment. Expand
Nosocomial bronchopneumonia in the critically ill. Histologic and bacteriologic aspects.
TLDR
The sensitivity and the specificity of the protected minibronchoalveolar lavage technique in the diagnosis of nosocomial BPN were found to be 70 and 69%, respectively. Expand
Mycobacterial cell wall: structure and role in natural resistance to antibiotics.
TLDR
The cell wall barrier alone cannot produce significant levels of drug resistance, which requires synergistic contribution from a second factor, such as the enzymatic inactivation of drugs. Expand
Antimicrobial resistance: a global view from the 2013 World Healthcare-Associated Infections Forum
TLDR
The general public must continue to be made aware of the current scale of AMR’s threat, and must perceive antimicrobials as they are: a non-renewable and endangered resource. Expand
Detection by GenoType MTBDRsl Test of Complex Mechanisms of Resistance to Second-Line Drugs and Ethambutol in Multidrug-Resistant Mycobacterium tuberculosis Complex Isolates
TLDR
The GenoType MTBDRsl test efficiently detects the most common mutations involved in resistance to fluoroquinolones, aminoglycosides/cyclic peptide, and ethambutol and accurately assesses susceptibility to amikacin. Expand
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