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Agonist and antagonist activities at benzodiazepine receptors of a novel series of quinoline derivatives.
- C. Gardner, R. Deacon, V. James, F. Parker, P. Budhram
- Chemistry, Medicine
- European journal of pharmacology
- 13 October 1987
Five members of a novel series of quinoline derivatives which all have similar activities on benzodiazepine receptor binding in vitro were compared in a food-motivated conflict and stress-induced… Expand
Activity of some benzodiazepine receptor ligands with reduced sedative and muscle relaxant properties on stress-induced electrocorticogram arousal in sleeping rats.
Arousal of the electrocorticogram induced by intermittent footshocks in sleeping rats was originally developed to detect hypnotic compounds. A modified shortened protocol is described in which a… Expand
Actions and interactions of benzodiazepine agonists, antagonists and inverse agonists on suprahyoid muscle twitching.
Amphetamine-induced twitching of the suprahyoid muscle in nialamide-pretreated, urethane-anaesthetised rats was inhibited by the benzodiazepine agonists RU 32007, diazepam and chlordiazepoxide and… Expand
Reversal of stress‐induced arousal in sleeping rats by some imidazopyrimidine benzodiazepine receptor ligands
Five selected imidazopyrimidine ligands for benzodiazepine receptors which show nonsedative anxiolytic behavioral profiles, were tested for their ability to reverse arousal induced by intermittent… Expand
During Angiotensin-Converting Enzyme Inhibition Bradykinin Type 2 Receptor BE 1 Genotype Influences Bradykinin-Dependent
To test the hypothesis that the bradykinin receptor 2 (BDKRB2) BE1 9/ 9 polymorphism affects vascular responses to bradykinin, we measured the effect of intra-arterial bradykinin on forearm blood… Expand