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The insulin-like growth factor-binding protein (IGFBP) superfamily.
Over the last decade, the concept of an IGFBP family has been well accepted, based on structural similarities and on functional abilities to bind IGFs with high affinities. The existence of otherExpand
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The Neisseria meningitidis haemoglobin receptor: its role in iron utilization and virulence
The Neisseris meningitidis haemoglobin receptor gene, hmbR, was cloned by complementation in a porphyrin‐requiring Escherichia coli mutant. hmbR encodes an 89.5 kDa outer membrane protein whichExpand
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Growth hormone insensitivity associated with a STAT5b mutation.
This report documents that the syndrome of growth hormone insensitivity (severe short stature, increased secretion of growth hormone, but low serum concentrations of insulin-like growth factor IExpand
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The Growth Hormone Cascade and Its Role in Mammalian Growth
The myriad actions of growth hormone (GH) are still incompletely understood, despite decades of research. Although it is a major regulator of post-natal growth in mammals, much of its effects onExpand
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Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP Superfamily.
The protein product of the novH oncogene, a member of the CCN family, is structurally related to the insulin-like growth factor (IGF) binding proteins (IGFBPs). We have characterized aspects ofExpand
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STAT5b deficiency: lessons from STAT5b gene mutations.
Growth hormone (GH) regulates insulin-like growth factor (IGF)-I production primarily through activation of the GH receptor (GHR)-signal transducer and activator of transcription (STAT)-5b signalingExpand
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STAT5b deficiency: an unsuspected cause of growth failure, immunodeficiency, and severe pulmonary disease.
Over the past 20 years, more than 150 new genetic disorders related to primary immunodeficiencies have been described, most of which initially present in the pediatric population. 1 PediatricExpand
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Evidence for a continuum of genetic, phenotypic, and biochemical abnormalities in children with growth hormone insensitivity.
GH insensitivity (GHI) presents in childhood as growth failure and in its severe form is associated with dysmorphic and metabolic abnormalities. GHI may be caused by genetic defects in the GH-IGF-IExpand
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Severe growth hormone insensitivity resulting from total absence of signal transducer and activator of transcription 5b.
CONTEXT The central clinical feature of GH insensitivity (GHI) is severe growth failure associated with elevated serum concentrations of GH and abnormally low serum levels of IGF-I. GHI can be theExpand
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Insulin‐like growth factor binding proteins: a proposed superfamily
Hwa V, Oh Y, Rosenfeld RG. Insulin‐like growth factor binding proteins: a proposed superfamily. Acta Pzdiatr 1999; Suppl 428:37‐45. Stockholm. ISSN 0803‐5326
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