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Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in
TLDR
It is suggested that in the absence of external stimuli, the PAG–Csk complex transmits negative regulatory signals and thus may help to keep resting T cells in a quiescent state. Expand
GPI-anchored cell-surface molecules complexed to protein tyrosine kinases.
TLDR
The GPI-linked human molecules CD59, CD55, CD48, CD24, and CD14 as well as the mouse molecules Thy-1 and Ly-6 were found to associate with protein tyrosine kinases, key regulators of cell activation and signal transduction. Expand
Phosphorylation-Dependent Regulation of T-Cell Activation by PAG/Cbp, a Lipid Raft-Associated Transmembrane Adaptor
TLDR
Data provided provide firm evidence that PAG is a bona fide negative regulator of T-cell activation as a result of its capacity to recruit Csk and suggest that the inhibitory function of PAG in T cells is suppressed by CD45, and support the idea that dephosphorylation of proteins on tyrosine residues is critical for the initiation of T cell activation. Expand
Tetraspan microdomains distinct from lipid rafts enrich select peptide–MHC class II complexes
TLDR
The organization of uniformly loaded peptide–MHC class II complexes in tetraspan domains may be a very early event that determines both the composition of the immunological synapse and the quality of the subsequent T helper cell response. Expand
The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.
TLDR
A hierarchical regulation among SFK members to fine-tune mast cell activation is revealed and is revealed via both Lyn-dependent and Lyn-independent mechanisms. Expand
Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules.
TLDR
These new monoclonal antibodies represent valuable tools to study the expression of HLA-G and Hla-E molecules in cells and tissues under normal and pathologic conditions. Expand
Non–T Cell Activation Linker (NTAL)
TLDR
A novel transmembrane adaptor protein, termed NTAL (non–T cell activation linker) is the product of a previously identified WBSCR5 gene of so far unknown function and appears to be a structural and possibly also functional homologue of LAT in non–T cells. Expand
GPI-microdomains: a role in signalling via immunoreceptors.
TLDR
Recent results suggest that these membrane specializations mediate not only signal transduction via GPI-proteins and glycolipids but also play important roles in initiation of signalling via immunoreceptors. Expand
Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes.
TLDR
It is shown that receptor-induced tyrosine phosphorylation of NTAL and concomitant Grb2 complex formation critically modulate the Ca(2+) response without affecting SLP-65 and PLC-gamma2 phosphorylated proteins. Expand
Biochemical characterization of a soluble form of the 53‐kDa monocyte surface antigen
TLDR
Two monoclonal antibodies were prepared which recognize a monocyte 53‐kDa antigen which was found in most normal sera and in urine of some nephrotic patients and indicates that it is the antigen previously called MY‐4 or MY‐23. Expand
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