V. Homburger

Publications68
h-index26
Citations2,341
Highly Influential Citations71
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Proteomic Analysis of Astrocytic Secretion in the Mouse
Astrocytes, the most abundant cell type in the central nervous system, are intimately associated with synapses. They play a pivotal role in neuronal survival and the brain inflammatory response. Some… Expand
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The Heterotrimeric Protein Go Is Required for the Formation of Heart Epithelium in Drosophila
The gene encoding the α subunit of the Drosophila Go protein is expressed early in embryogenesis in the precursor cells of the heart tube, of the visceral muscles, and of the nervous system. This… Expand
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Differential G protein-mediated coupling of D2 dopamine receptors to K+ and Ca2+ currents in rat anterior pituitary cells
In anterior pituitary cells, dopamine, acting on D2 dopamine receptors, concomitantly reduces calcium currents and increases potassium currents. These dopamine effects require the presence of… Expand
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Cytokine signals propagate through the brain
Interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) are proinflammatory cytokines that are constitutively expressed in healthy, adult brain where they mediate normal neural functions such as… Expand
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Direct Interaction Enables Cross-talk between Ionotropic and Group I Metabotropic Glutamate Receptors*
Functional interplay between ionotropic and metabotropic receptors frequently involves complex intracellular signaling cascades. The group I metabotropic glutamate receptor mGlu5a co-clusters with… Expand
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Cytokine signals propagate through the brain
Interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) are proinflammatory cytokines that are constitutively expressed in healthy, adult brain where they mediate normal neural functions such as… Expand
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Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability
Synaptic activity–dependent remodeling of the glutamate receptor scaffold complex generates a negative feedback loop that limits further NMDA receptor activation.
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Specific antibodies against Go isoforms reveal the early expression of the Go2 alpha subunit and appearance of Go1 alpha during neuronal differentiation.
We have previously identified two isoforms of Go alpha in membranes of N1E-115 neuroblastoma cells, using an antibody raised against the purified Go alpha subunit; one isoform of the Go alpha subunit… Expand
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Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein.
We have characterized a G-protein-coupled glutamate receptor in primary cultures of striatal neurons. Glutamate, quisqualate, or trans-1-aminocyclopentane-1,3-dicarboxylate inhibited by 30-40% either… Expand
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Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transfer.
Despite the fact that numerous studies suggest the existence of receptor multiprotein complexes, visualization and monitoring of the dynamics of such protein assemblies remain a challenge. In this… Expand
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