• Publications
  • Influence
Manipulation of Host Hepatocytes by the Malaria Parasite for Delivery into Liver Sinusoids
The merozoite stage of the malaria parasite that infects erythrocytes and causes the symptoms of the disease is initially formed inside host hepatocytes. However, the mechanism by which hepaticExpand
  • 503
  • 19
  • PDF
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
The fatty acid synthesis type II pathway has received considerable interest as a candidate therapeutic target in Plasmodium falciparum asexual blood-stage infections. This apicoplast-residentExpand
  • 251
  • 16
  • PDF
Transformation of leukocytes by Theileria parva and T. annulata.
Theileria parva and T. annulata provide intriguing models for the study of parasite-host interactions. Both parasites possess the unique property of being able to transform the cells they infect; T.Expand
  • 146
  • 15
Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells.
Immunization with Plasmodium sporozoites that have been attenuated by gamma-irradiation or specific genetic modification can induce protective immunity against subsequent malaria infection. TheExpand
  • 260
  • 12
  • PDF
Behavioural and histopathological alterations in mice with cerebral malaria
Different features of sensorimotor function and behaviour were studied in murine cerebral malaria (CM) and malaria without cerebral involvement (non‐CM) applying the primary screen of the SHIRPAExpand
  • 109
  • 11
Cloning of a protease gene family of Fasciola hepatica by the polymerase chain reaction.
Degenerate oligonucleotide primers derived from conserved cysteine protease sequences were used in the reverse transcription polymerase chain reaction to amplify seven different cysteine proteaseExpand
  • 85
  • 10
A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress
Plasmodium parasite entrance and exit Sweats and fever are the hallmarks of malaria. Red blood cells are the replication factories for malaria parasites. Fever occurs when the parasites' merozoiteExpand
  • 50
  • 8
  • PDF
Inhibition of apoptosis by intracellular protozoan parasites.
Protozoan parasites which reside inside a host cell avoid direct destruction by the immune system of the host. The infected cell, however, still has the capacity to counteract the invasive pathogenExpand
  • 162
  • 7
Evolution and architecture of the inner membrane complex in asexual and sexual stages of the malaria parasite.
The inner membrane complex (IMC) is a unifying morphological feature of all alveolate organisms. It consists of flattened vesicles underlying the plasma membrane and is interconnected with theExpand
  • 74
  • 7
The intracellular parasite Theileria parva protects infected T cells from apoptosis.
Parasites have evolved a plethora of strategies to ensure their survival. The intracellular parasite Theileria parva secures its propagation and spreads through the infected animal by infecting andExpand
  • 89
  • 6
  • PDF