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A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA.
Although SSAGA was designed to provide for broad phenotyping of alcoholism, review of its new features suggests its suitability for a variety of family studies, not just those focusing on substance abuse.
Variants in nicotinic receptors and risk for nicotine dependence.
This study confirms that at least two independent variants in this nicotinic receptor gene cluster contribute to the development of habitual smoking in some populations, and it underscores the importance of multiple genetic variants contributing to theDevelopment of common diseases in various populations.
Genome-wide search for genes affecting the risk for alcohol dependence.
There was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations.
Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.
The very strong association of GABRA2 with both alcohol dependence and the beta frequency of the electroencephalogram, combined with biological evidence for a role of this gene in both phenotypes, suggest that GABra2 might influence susceptibility to alcohol dependence by modulating the level of neural excitation.
A genome-wide association study of alcohol dependence
The dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence.
Types of alcoholics, I. Evidence for an empirically derived typology based on indicators of vulnerability and severity.
An empirical clustering technique was applied to data obtained from 321 male and female alcoholics to identify homogeneous subtypes having discriminative and predictive validity and suggest that an empirically derived, multivariate typology of alcoholism has theoretical implications for explaining the heterogeneity among alcoholics and may provide a useful basis for predicting course and estimating treatment response.
Comparison of direct interview and family history diagnoses of alcohol dependence.
A recursive equation is derived to combine a variable number of family history reports, wherein the probabilities associated with a single report are computed from the logistic analysis, which permits the use offamily history information both as a proxy for an uninterviewed relative, as well as a second source of information to be used in the analysis of genetic family data.
A validity study of the SSAGA--a comparison with the SCAN.
- M. Hesselbrock, C. Easton, K. Bucholz, M. Schuckit, V. Hesselbrock
- Psychology, MedicineAddiction
- 1 September 1999
Results from this study and two previous studies which examined reliability indicate that the SSAGA is a highly reliable and valid instrument for use in studies of a variety of psychiatric disorders, including alcohol and drug dependence.
Allelic and haplotypic association of GABRA2 with alcohol dependence
- J. Covault, J. Gelernter, V. Hesselbrock, M. Nellissery, H. Kranzler
- MedicineAmerican journal of medical genetics. Part B…
- 15 August 2004
Ten single nucleotide polymorphisms spanning the coding region of this gene were examined in samples of European American subjects with alcohol dependence, and controls screened to exclude substance use disorders, which underscore the potential contribution of polymorphic variation at the GABRA2 locus to the risk for alcohol dependence.
Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis.
There was strong evidence that variations in ADH4 are associated with alcoholism: 12 SNPs were significantly associated and the region of strongest association ran from intron 1 to 19.5 kb beyond the 3' end of the gene.