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Fiji: an open-source platform for biological-image analysis
TLDR
Fiji is a distribution of the popular open-source software ImageJ focused on biological-image analysis that facilitates the transformation of new algorithms into ImageJ plugins that can be shared with end users through an integrated update system. Expand
Systematic determination of patterns of gene expression during Drosophila embryogenesis
TLDR
Analyzing gene-expression patterns by in situ hybridization to whole-mount embryos provides an extremely rich dataset that can be used to identify genes involved in developmental processes that have been missed by traditional genetic analysis. Expand
The drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system
TLDR
Molecular and developmental analyses reveals that the sine oculis (so) locus encodes a homeodomain-containing protein that is expressed and required in the unpatterned epithelium prior to morphogenesis, and argues that so plays an essential role in controlling the initial events of pattern formation in the eye disc. Expand
The development of cellular junctions in the Drosophila embryo.
TLDR
The pattern and development of cellular junctions in the different tissues of the Drosophila embryo from the blastoderm stage until hatching were analyzed and interesting exceptions to the general pattern of junctional development are provided by the outer epithelial layer of the proventriculus and the Malpighian tubules. Expand
TrakEM2 Software for Neural Circuit Reconstruction
TLDR
A software application, TrakEM2, is designed that addresses the systematic reconstruction of neuronal circuits from large electron microscopical and optical image volumes and addresses the challenges of image volume composition from individual, deformed images. Expand
Specification of Drosophila hematopoietic lineage by conserved transcription factors.
TLDR
Two major classes of cells observed within the Drosophila hematopoietic repertoire are plasmatocytes/macrophages and crystal cells, and the similarities of Srp and Lz to mammalian GATA and AML1 proteins are likely to have broad implications for understanding mammalian hematoplasts and leukemias. Expand
Embryonic origin of hemocytes and their relationship to cell death in Drosophila.
TLDR
It is shown that, in the Drosophila embryo, apoptosis can occur independently of macrophages, since mutations lacking macrophage show abundant cell death. Expand
shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia.
TLDR
It is reported here that DE-cadherin is encoded by the shotgun (shg) gene, and it is found that suppression of morphogenetic movements rescues the zygotic shg phenotype. Expand
A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors
TLDR
The posterior signalling centre (PSC) functions as a haematopoietic niche that is essential for the maintenance of blood cell precursors in Drosophila and is identified early in the embryo by the homeotic gene Antp and expresses the signalling molecule Hedgehog. Expand
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