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SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene
- V. Lefebvre, W. Huang, V. Harley, P. Goodfellow, B. de Crombrugghe
- Biology, MedicineMolecular and cellular biology
- 1 April 1997
The results strongly suggest a model whereby SOX9 is involved in the control of the cell-specific activation of COL2A1 in chondrocytes, an essential component of the differentiation program of these cells.
Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds
- S. Silva, A. Hacker, V. Harley, P. Goodfellow, A. Swain, R. Lovell-Badge
- BiologyNature Genetics
- 1 September 1996
It is found that Sox9 expression closely follows differentiation of Sertoli cells in the mouse testis, in experimental sex reversal when fetal ovaries are grafted to adult kidneys and in the chick where there is no evidence for a Sry gene.
Direct Regulation of Adult Brain Function by the Male-Specific Factor SRY
SRY, like HMG1, recognizes sharp angles in DNA.
- S. Ferrari, V. Harley, A. Pontiggia, P. Goodfellow, R. Lovell-Badge, M. Bianchi
- BiologyThe EMBO journal
- 1 December 1992
It is shown here also that the HMG box of SRY, the protein that determines the expression of male‐specific genes in humans, recognizes four‐way junction DNAs irrespective of their sequence.
BMP Receptor Signaling Is Required for Postnatal Maintenance of Articular Cartilage
Regulatory information from the mouse Gdf5 gene is used to develop new mouse lines that can be used to either activate or inactivate genes specifically in developing joints, to test the role of BMP receptor signaling in joint development.
Identification of SOX3 as an XX male sex reversal gene in mice and humans.
SOX3 and SRY are functionally interchangeable in sex determination and support the notion that SRY evolved from SOX3 via a regulatory mutation that led to its de novo expression in the early gonad.
Loss of Fgfr2 leads to partial XY sex reversal.
Definition of a consensus DNA binding site for SRY.
The HMG box family is functionally diverse, with members involved in DNA recognition during nucleosome assembly, recombination and transcription likely to be transcription factors and include the mammalian testis deteimnining factor (SRY), T-cell factor, lymphoid enhancer factor and the yeast sterility factor.
Boys, girls and shuttling of SRY and SOX9
DNA binding activity of recombinant SRY from normal males and XY females.
The protein encoded by the human testis determining gene, SRY, contains a high mobility group (HMG) box related to that present in the T cell-specific, DNA-binding protein TCF-1. Recombinant SRY…