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Tick salivary gland extracts promote virus growth in vitro.
Saliva of blood-feeding arthropods promotes infection by the vector-borne pathogens they transmit. To investigate this phenomenon in vitro, cultures of mouse L cells were treated with a salivaryExpand
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Anti‐interleukin‐8 activity of tick salivary gland extracts
Interleukin‐8 (IL‐8) is one of many mammalian chemokines (chemotactic cytokines) that direct mammalian inflammatory and immune cells to sites of injury and infection. Chemokines are produced locallyExpand
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Manipulation of host cytokine network by ticks: a potential gateway for pathogen transmission.
Ticks are obligatory blood-feeding arthropods that secrete various immunomodulatory molecules to antagonize host inflammatory and immune responses. Cytokines play an important role in regulatingExpand
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Anti-chemokine activities of ixodid ticks depend on tick species, developmental stage, and duration of feeding.
Ixodid ticks require comparatively large bloodmeals for their development and survival. Blood-feeding elicits signaling events in the host leading to wound healing responses (hemostasis,Expand
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Effect of fast protein liquid chromatography fractionated salivary gland extracts from different ixodid tick species on interleukin-8 binding to its cell receptors.
Interleukin-8 plays a critical role in inflammatory processes. Hence generation of molecules with anti-IL-8 activity is likely to be important for successful feeding and for survival of the ticks.Expand
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Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1.
The effect of the crude extract and of two alkaloid fractions prepared from Mahonia aquifolium on interleukin-8 (IL-8) production in the lipopolysaccharide (LPS)-stimulated human monocytic cell lineExpand
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Differential anti‐chemokine activity of Amblyomma variegatum adult ticks during blood‐feeding
Ticks secrete a cocktail of immunomodulatory molecules in their saliva during blood‐feeding, including chemokine‐binding factors that help control the activity of host immunocompetent cells. Here weExpand
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Ixodid tick salivary gland extracts inhibit production of lipopolysaccharide-induced mRNA of several different human cytokines
Extracts prepared from the salivary glands (SGE) of partially fed adult female Rhipicephalus appendiculatus ticks reduced the expression by human peripheral blood leukocytes (PBLs) ofExpand
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Significance of anti-interferon-alpha2 and sICAM-1 activities in the sera of viral hepatitis B and C patients treated with human recombinant interferon-alpha2.
In this study the presence of an IFN-binding activity in the sera of patients with chronic viral hepatitis B or C treated with rIFN-alpha2 was screened by a radioimmune assay (RIA) using radiolabeledExpand
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Electrophoretic profiles and activities of human interferon in heterologous cells.
Human leukocyte interferon (IF) was found active in homologous human and heterologous rodent cells both in antiviral tests and in tests measuring cell-growth inhibitory activity. About 10 times more u
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