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Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells.
The SAR analysis of these phenolic compounds revealed three important structural features that affect COX-2 inhibition: lipophilicity of the alkyl side chain, and substitution pattern of hydroxy and carbonyl groups on the side chain. Expand
Chemistry and Pharmacology of Gynostemma pentaphyllum
In traditional Chinese medicine, Gynostemma pentaphyllum (Thunb.) Makino is a herbal drug of extreme versatility and has been extensively researched in China. The dammarane saponins isolated fromExpand
Gingerols: a novel class of vanilloid receptor (VR1) agonists
It is concluded that gingerols represent a novel class of naturally occurring VR1 receptor agonists that may contribute to the medicinal properties of ginger, which have been known for centuries. Expand
Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger.
Paradol, a natural constituent of ginger, was found to be the most potent COX-1 inhibitor and anti platelet aggregation agent. Expand
The stability of gingerol and shogaol in aqueous solutions.
It was found that gingerol exhibited novel reversible kinetics, in which it undergoes dehydration-hydration transformations with shogaol, the major degradation product, and degradation rates were found to be pH dependent with greatest stability observed at pH 4. Expand
Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation.
The results suggest that the inhibition of the expression of cyclooxygenase-2 and inducible nitric oxide by harpagoside involves suppression of NF-kappaB activation, thereby inhibiting downstream inflammation and subsequent pain events. Expand
Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity.
Results show that ZTX42 and [6]-DHP suppress NO production in murine macrophages by partially inhibiting iNOS enzymatic activity and reducing iNos protein production, via attenuation of NF-kappaB-mediated iN OS gene expression, providing a rationale for the anti-inflammatory activity reported for this class of compounds. Expand
Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation.
The results provide a basis for the design of more potent synthetic gingerol analogues, with similar potencies to aspirin, as platelet activation inhibitors with potential value in cardiovascular disease. Expand
Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review
Ginger has shown prominent protective effects on diabetic liver, kidney, eye, and neural system complications and the pharmacokinetics, bioavailability, and the safety issues of ginger are discussed in this update. Expand
Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubes.
The enhancement of glucose uptake in L6 rat skeletal muscle cells by the gingerol pungent principles of the ginger extract supports the potential of ginger and its pungents for the prevention and management of hyperglycemia and type 2 diabetes. Expand