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Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate
Astrocytes establish rapid cell-to-cell communication through the release of chemical transmitters. The underlying mechanisms and functional significance of this release are, however, not wellExpand
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Glutamate exocytosis from astrocytes controls synaptic strength
The release of transmitters from glia influences synaptic functions. The modalities and physiological functions of glial release are poorly understood. Here we show that glutamate exocytosis fromExpand
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Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters
Three closely related proteins transport glutamate into synaptic vesicles for release by exocytosis. Complementary patterns of expression in glutamatergic terminals have been reported for VGLUT1 andExpand
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Muscular performance after concentric and eccentric exercise in trained men.
PURPOSE We studied previously resistance-trained men and compared the effects of concentric and eccentric training on performance and structural muscle parameters. METHODS Seventeen trainedExpand
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GABA and GABAA receptors at hippocampal mossy fibre synapses
Anatomical and electrophysiological evidence has raised the possibility that corelease of GABA and glutamate occurs at hippocampal mossy fibre synapses which, however, lack the vesicular GABAExpand
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Functional and anatomical identification of a vesicular transporter mediating neuronal ATP release.
ATP is known to be coreleased with glutamate at certain central synapses. However, the nature of its release is controversial. Here, we demonstrate that ATP release from cultured rat hippocampalExpand
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Immunogold detection of L-glutamate and D-serine in small synaptic-like microvesicles in adult hippocampal astrocytes.
Glutamate and the N-methyl-D-aspartate receptor ligand D-serine are putative gliotransmitters. Here, we show by immunogold cytochemistry of the adult hippocampus that glutamate and D-serineExpand
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Synaptic Vesicular Localization and Exocytosis ofl-Aspartate in Excitatory Nerve Terminals: A Quantitative Immunogold Analysis in Rat Hippocampus
To elucidate the role of aspartate as a signal molecule in the brain, its localization and those of related amino acids were examined by light and electron microscopic quantitativeExpand
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Morphological evidence for vesicular glutamate release from astrocytes
There is now growing evidence that astrocytes, like neurons, can release transmitters. One transmitter that in a vast number of studies has been shown to be released from astrocytes is glutamate.Expand
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Glycine, GABA and their transporters in pancreatic islets of Langerhans: evidence for a paracrine transmitter interplay
To elucidate the possible roles of the CNS neurotransmitters glycine and GABA in neuroendocrine paracrine signalling, we investigated their localizations, and those of their transport proteins, byExpand
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