Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum.
Drug discovery from natural products
- V. Gullo, J. McAlpine, K. S. Lam, D. Baker, F. Petersen
- Biology, ChemistryJournal of Industrial Microbiology…
- 17 March 2006
This review describes recent progress in drug discovery from natural sources including several examples of compounds that inhibit novel drug targets.
Antimicrobials, drug discovery, and genome mining
- R. Scheffler, S. Colmer, H. Tynan, A. Demain, V. Gullo
- Biology, MedicineApplied Microbiology and Biotechnology
- 1 February 2013
With the advent of genome sequencing, new antibiotics are being found by the techniques of genome mining, offering hope for the future.
Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties
The avermectins, a family of new anthelmintic agents, were isolated from the mycelia of Streptomyces avermitilis. Four closely related major components and four homologous minor components were…
A novel class of antitumor metabolites from the fungus Nattrassia Mangiferae
Structure elucidation of a new antifungal sterol sulfate, Sch 575867, from a deep-water marine sponge (Family: Astroscleridae).
It is described as a red-orange, rock hard, 15cm spherical sponge, with a thin veneer of living tissue over an aragonite skeleton, which is porous and smooth, with 2cm diameter mounds.
The discovery of natural products with therapeutic potential.
- V. Gullo
- Biology, ChemistryBiotechnology
The source of Chemical Diversity Aerobic Actinomycetes, Bacterias a Source of Novel Therapeutics, The potential of Fungi in the Discovery of Novel, Low Molecular Weight pharmaceuticals, and Strategies for Discovering Antiviral Agents from Natural Products.
Chemokine receptor CCR-5 inhibitors produced by Chaetomium globosum.
Two novel chemokine receptor CCR-5 inhibitors were isolated from the fungal fermentation broth of Chaetomium globosum by normal- and reversed-phase HPLC purifications and the structure and relative configuration of 2 were determined unequivocally by X-ray crystallographic analysis.
A new antitumor compound from the plant Oryctanthus sp. as a VEGF receptor binding inhibitor.