AmphoraNet: the webserver implementation of the AMPHORA2 metagenomic workflow suite.
Effect of metformin on methylglyoxal metabolism in patients with type 2 diabetes.
Previous findings that metformin can reduce plasma MG in type 2 diabetic patients are supported, given the observed increase in Glo1 activity, this reduction is due not only to the scavenging properties of met formin, but the restoration of Glo 1 activity.
The “Giant Virus Finder” discovers an abundance of giant viruses in the Antarctic dry valleys
A bioinformatics work-flow is described that is capable of discovering the likely presence of the genomes of giant viruses in metagenomic shotgun-sequenced datasets, and it is shown that most of these samples contain giant viruses, especially in the Antarctic dry valleys.
Near Perfect Protein Multi-Label Classification with Deep Neural Networks
SECLAF: a webserver and deep neural network design tool for hierarchical biological sequence classification
SECLAF, a webserver that uses deep neural networks for hierarchical biological sequence classification, is introduced, and by applying SECLAF for residue-sequences, it is reported the most accurate multi-label protein classifier to date.
MEN1 mutations and potentially MEN1-targeting miRNAs are responsible for menin deficiency in sporadic and MEN1 syndrome-associated primary hyperparathyroidism
Inherited, germline mutations of menin-coding MEN1 gene cause multiple endocrine neoplasia type 1 (MEN1), while somatic MEN1 mutations are the sole main driver mutations in sporadic primary…
Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification
A thorough review of the literature on the role of single nucleotide polymorphisms (SNPs) as key agents affecting the viral entry of SARS-CoV-2 and innate immunity found several SNPs found to alter susceptibility to various bacterial and viral infections.
Lack of association between C385A functional polymorphism of the fatty acid amide hydrolase gene and polycystic ovary syndrome.
The data indicate that the C385A polymorphism of the fatty acid amide hydrolase gene is not a genetic susceptibility factor for the development of polycystic ovary syndrome, however, the polymorphism might have a role in influencing the synthesis or metabolism of different hormones including thyroxin and insulin.
Cell cycle dependent RRM2 may serve as proliferation marker and pharmaceutical target in adrenocortical cancer.
- V. Grolmusz, K. Karászi, A. Patócs
- Biology, MedicineAmerican Journal of Cancer Research
- 1 September 2016
Based on the comparative reanalysis of the transcriptional malignancy signature with the cell cycle dependent transcriptional program of ACC, ribonucleotide reductase subunit 2 (RRM2) has been validated as cell cycle dependently expressed and revealed a strong correlation with Ki67 index in ACC.