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Statistically significant association of the single nucleotide polymorphism (SNP) rs13181 (ERCC2) with predisposition to Squamous Cell Carcinomas of the Head and Neck (SCCHN) and Breast cancer in the…
- A. Mitra, Neetu Singh, V. Garg, Rashmi Chaturvedi, Mandira Sharma, S. Rath
- Medicine, Biology
- Journal of experimental & clinical cancer…
- 18 July 2009
BackgroundNon-synonymous single nucleotide polymorphisms (SNPs) within vital DNA repair genes may cause reduction of activity leaving the genome unrepaired resulting in genomic instability and… Expand
Novel functional role of heat shock protein 90 in ATP-sensitive K+ channel-mediated hypoxic preconditioning.
AIMS ATP-sensitive K+ (K ATP) channels are implicated in the protective effect of ischaemic preconditioning (IPC). Kir6.2 has been shown to be involved in the cardioprotection of IPC. However, the… Expand
Protein kinase C isoform-dependent modulation of ATP-sensitive K+ channels in mitochondrial inner membrane.
The ATP-sensitive K(+) (K(ATP)) channels in both sarcolemmal (sarcK(ATP)) and mitochondrial inner membrane (mitoK(ATP)) are the critical mediators in cellular protection of ischemic preconditioning… Expand
Association of CYP1A1 polymorphisms with breast cancer in North Indian women.
Cytochrome P-450 (CYP) 1A1 is a candidate gene for low penetrance breast cancer (BC) susceptibility. Evidences demonstrate that ethnic differences in BC incidence may be partly due to genetic… Expand
Tuning of EAG K+ channel inactivation: Molecular determinants of amplification by mutations and a small molecule
- V. Garg, F. Sachse, M. Sanguinetti
- Chemistry, Medicine
- The Journal of general physiology
- 1 September 2012
Ether-à-go-go (EAG) and EAG-related gene (ERG) K+ channels are close homologues but differ markedly in their gating properties. ERG1 channels are characterized by rapid and extensive C-type… Expand
Molecular Determinants for Activation of Human Ether-à-go-go-related Gene 1 Potassium Channels by 3-Nitro-N-(4-phenoxyphenyl) Benzamide
- V. Garg, A. Stary-Weinzinger, F. Sachse, M. Sanguinetti
- Biology, Medicine
- Molecular Pharmacology
- 8 July 2011
Human ether-à-go-go-related gene 1 (hERG1) channels mediate repolarization of cardiac action potentials. Inherited long QT syndrome (LQTS) caused by loss-of-function mutations, or unintended blockade… Expand
Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes.
AIMS ATP-sensitive potassium (K(ATP)) channels in the heart are critical regulators of cellular excitability and action potentials during ischaemia. However, little is known about subcellular… Expand
Activation of Slo2.1 channels by niflumic acid
Slo2.1 channels conduct an outwardly rectifying K+ current when activated by high [Na+]i. Here, we show that gating of these channels can also be activated by fenamates such as niflumic acid (NFA),… Expand
Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes as Models for Cardiac Channelopathies: A Primer for Non-Electrophysiologists
- Priyanka Garg, V. Garg, Rajani Shrestha, M. Sanguinetti, T. Kamp, Joseph C. Wu
- Circulation research
- 6 July 2018
Life threatening ventricular arrhythmias leading to sudden cardiac death are a major cause of morbidity and mortality. In the absence of structural heart disease, these arrhythmias, especially in the… Expand
HLA-B∗ 1502 is associated with carbamazepine induced Stevens-Johnson syndrome in North Indian population.
- R. Aggarwal, Madhulika Sharma, M. Modi, V. Garg, Manilla Salaria
- Human immunology
- 1 November 2014
The evidence of association between HLA-B(∗)1502 and anticonvulsant induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) from the Indian population is scant. Patients with a… Expand