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Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata
It is believed that lucifensin is that long-sought larger molecular weight antimicrobial factor of the Lucilia sericata excretions/secretions believed to be effective against pathogenic elements of the wound microbial flora. Expand
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells
Recently, we have isolated and characterized remarkable antimicrobial peptides (AMPs) from the venom reservoirs of wild bees. These peptides (melectin, lasioglossins, halictines and macropin) andExpand
Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae)
Three novel structurally related pentadecapeptides, named lasioglossins, were isolated from the venom of the eusocial bee Lasioglossum laticeps and exhibited potent antimicrobial activity against both Gram‐positive and Gram‐negative bacteria, low haemolytic and mast cell degranulation activity, and a potency to kill various cancer cells in vitro. Expand
Melectin: A Novel Antimicrobial Peptide from the Venom of the Cleptoparasitic Bee Melecta albifrons
The results of biological testing suggest that a Pro kink in the α‐helical structure of melectin plays an important role in selectivity for bacterial cells. Expand
On the induction of segment extension and chromatid structural changes in Vicia faba chromosomes after treatment with 5-azacytidine and 5-azadeoxycytidine.
The preliminary conclusion drawn from the experimental results is that segment extension is due to the inhibition of RNA and, concomitantly, protein synthesis or the failure of complex formation between DNA and specific proteins. Expand
New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs
Four new peptides of the mastoparan family synthesized and tested for antimicrobial potency against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa showed that the peptides might adopt alpha-helical conformation in such anisotropic environments. Expand
Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study
The total chemical synthesis of this peptide of 40 amino acid residues and three intramolecular disulfide bridges by using three different protocols yielded a peptide with a pattern of disulfides bridges identical to that of native lucifensin. Expand
Lasiocepsin, a novel cyclic antimicrobial peptide from the venom of eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae)
The synthetic lasiocepsin possessed antimicrobial activity against both Gram-positive and -negative bacteria, antifungal activity against Candida albicans, and no hemolytic activity against human erythrocytes. Expand
Cloning and characterization of the str operon and elongation factor Tu expression in Bacillus stearothermophilus.
The results suggest that the oppositely adjusted core promoters significantly contribute to the differential expression of the str operon genes, as monitored by the expression of EF-Tu and EF-G. Expand
Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity
The synthesis and biological activities of 23 new analogues of MEP are described, including the influence of dimerization and tetramerization on the antimicrobial and hemolytic activities, as well as the role of Met in positions 14 and 17 of the peptide chain. Expand