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Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity
The bacteriophage population is large, dynamic, ancient, and genetically diverse. Limited genomic information shows that phage genomes are mosaic, and the genetic architecture of phage populations… Expand
Local invasiveness of ameloblastoma. Role played by matrix metalloproteinases and proliferative activity
- J. J. V. Pinheiro, V. Freitas, A. I. Moretti, A. G. Jorge, R. G. Jaeger
- Biology, Medicine
- 1 July 2004
Aims: Ameloblastoma is an odontogenic neoplasm characterized by local invasiveness and recurrence. In this study we analysed the role played by matrix metalloproteinases (MMPs) in the local… Expand
MYC, FBXW7 and TP53 copy number variation and expression in Gastric Cancer
BackgroundMYC deregulation is a common event in gastric carcinogenesis, usually as a consequence of gene amplification, chromosomal translocations, or posttranslational mechanisms. FBXW7 is a… Expand
Brain Intraventricular Injection of Amyloid-β in Zebrafish Embryo Impairs Cognition and Increases Tau Phosphorylation, Effects Reversed by Lithium
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with no effective treatment and commonly diagnosed only on late stages. Amyloid-β (Aβ) accumulation and exacerbated tau… Expand
SIKVAV, a laminin alpha1-derived peptide, interacts with integrins and increases protease activity of a human salivary gland adenoid cystic carcinoma cell line through the ERK 1/2 signaling pathway.
- V. Freitas, Vanessa F Vilas-Boas, +8 authors R. G. Jaeger
- The American journal of pathology
Adenoid cystic carcinoma is a frequently occurring malignant salivary gland neoplasm. We studied the induction of protease activity by the laminin-derived peptide, SIKVAV, in cells (CAC2) derived… Expand
Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion
- V. Freitas, J. D. do Amaral, +6 authors G. Machado-Santelli
- Medicine, Biology
- Molecular Cancer
- 5 January 2013
BackgroundADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in… Expand
Anti-Angiogenic and Anti-Metastatic Activity of Synthetic Phosphoethanolamine
Background Renal cell carcinoma (RCC) is the most common type of kidney cancer, and represents the third most common urological malignancy. Despite the advent of targeted therapies for RCC and the… Expand
Laminin-1 and SIKVAV a laminin-1-derived peptide, regulate the morphology and protease activity of a human salivary gland adenoid cystic carcinoma cell line.
In a previous paper, we demonstrated that laminin-1 and its derived peptide SIKVAV modulates the morphology of an adenoid cystic carcinoma cell line (CAC2 cells). Light microscopy of CAC2 cells grown… Expand
MDM2, P53, P21WAF1 and pAKT protein levels in genesis and behaviour of adenoid cystic carcinoma.
- Marina Vaz de Lima, Yonara Maria Freire Soares Marques, +5 authors A. Mantesso
- Biology, Medicine
- Cancer epidemiology
- 1 August 2009
BACKGROUND MDM2, P53, P21(WAF1) and pAKT are proteins associated with the balance between cell death and survival. There are many hypotheses regarding the role of these proteins in salivary gland… Expand
Expression of molecules related to AKT pathway as putative regulators of ameloblastoma local invasiveness.
- Rodolpho L Cecim, Hicso A F Carmo, +5 authors J. J. V. Pinheiro
- Biology, Medicine
- Journal of oral pathology & medicine : official…
- 1 February 2014
BACKGROUND Ameloblastoma is an odontogenic neoplasm with local invasiveness and high recurrence. We previously suggested that growth factors, matrix metalloproteinases (MMPs), and TIMPs influence… Expand