V. Flegler

Publications8
h-index3
Citations34
Highly Influential Citations1
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Structure of the Mechanosensitive Channel MscS Embedded in the Membrane Bilayer.
Since life has emerged, gradients of osmolytes over the cell membrane cause pressure changes in the cell and require tight regulation to prevent cell rupture. The mechanosensitive channel of small… Expand
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Capabilities of the Falcon III detector for single-particle structure determination
Abstract Direct electron detectors are an essential asset for the resolution revolution in electron cryo microscopy of biological objects. The direct detectors provide two modes of data acquisition;… Expand
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Think beyond the core: The impact of the hydrophilic corona on the drug solubilization using polymer micelles.
Polymeric micelles are typically characterized as core-shell structures. The hydrophobic core is considered as depot for hydrophobic molecules and the corona forming block acts as stabilizing and… Expand
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Capabilities of the Falcon III detector for single-particle structure determination.
Direct electron detectors are an essential asset for the resolution revolution in electron cryo microscopy of biological objects. The direct detectors provide two modes of data acquisition; the… Expand
  • 3
Inverse Thermogelation of Aqueous Triblock Copolymer Solutions into Macroporous Shear-Thinning 3D Printable Inks.
Amphiphilic block copolymers that undergo (reversible) physical gelation in aqueous media are of great interest in different areas including drug delivery, tissue engineering, regenerative medicine,… Expand
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small conductance mechanosensitive channel YbiO
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YnaI in an open-like conformation
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The MscS-like channel YnaI has a gating mechanism based on flexible pore helices
Significance Many biological processes are based on mechanosensitive channels which are stimulated by mechanical forces. In cell-walled organisms, the large family of MscS-like channels is extremely… Expand