• Publications
  • Influence
Stimulation of interleukin 1 and 3 production by retinoic acid in vitro.
The results show that retinoic acid, in physiological concentrations, exerts selective effects on interleukin production in vitro, and this stimulation of IL 1 and IL 3 release may explain some of the immunostimulatory effects of retinoids in vivo. Expand
The effect of light on glycogen turnover in the retina of the intact honeybee drone (Apis mellifera)
The drone retina is composed of two types of cells: the photoreceptors in which no glycogen has been detected by electron microscopy and the glial cells which have abundant glycogen stores, demonstrating an increase of glycogen turnover. Expand
Differential regulation of colony-stimulating factors and interleukin 2 production by cyclosporin A.
The present data show that production of IL-2 and IL-3, but not that of GM-CSF, is inhibited by CsA and suggest a differential control mechanism for lymphokine synthesis in T lymphocytes. Expand
Interleukin 2‐independent stimulation of rabbit chondrocyte collagenase and prostaglandin E2 production by an interleukin 1‐like factor
It is suggested that collagenase secretion by chondrocytes may be used as an IL 2‐insensitive assay for the detection of IL 1‐like factors. Expand
Influence of vitamin D3 metabolites on the production of interleukins 1,2 and 3.
It is suggested that 1,25(OH)2D3 might not be an immunoregulator per se, but makes use of the immune system to exert its influence on one of its classical targets, namely the bone, and possibly on other connective tissues. Expand
Influence of macrophage products on the release of plasminogen activator, collagenase, beta-glucuronidase and prostaglandin E2 by articular chondrocytes.
The time course and concentration-dependence of the effects observed indicate that the secretion of plasminogen activator and collagenase are influenced in a strictly reciprocal fashion by the macrophage products, suggesting that the factor acting on chondrocytes is produced by a variety of macrophages, and that its action is not species-restricted. Expand
T lymphocyte-dependent evolution of bacterial cell wall-induced hepatic granulomas.
Injection of streptococcal cell walls into susceptible rats results in dissemination of SCW primarily to the liver, spleen, bone marrow, and peripheral joints, and inhibition of T lymphocyte proliferation and lymphokine synthesis pharmacologically by cyclosporin A administration in euthymic animals inhibits SCW-induced hepatic granuloma development. Expand
Effect of bisphosphonates on production of interleukin 1-like activity by macrophages and its effect on rabbit chondrocytes.
The results provide no evidence for a direct inhibitory effect of bisphosphonates on either the production of IL-1-like activity or the action of interleukin 1 (IL-1)like activity on chondrocytes. Expand
Effect of synthetic calcium pyrophosphate and hydroxyapatite crystals on the interaction of human blood mononuclear cells with chondrocytes, synovial cells, and fibroblasts.
Synthetic calcium pyrophosphate dihydrate crystals and, to a lesser extent, synthetic hydroxyapatite crystals increased the amount of interleukin-1/mononuclear cell factor released by human bloodExpand
Influence of macrophage products on enzyme and prostaglandin E2 release by chondrocytes
Connective tissue cells produce and release proteases with broad substrate specificity. These enzymes are involved in the breakdown of the structural macromolecules of the connective tissue matrix.Expand