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In vivo analgesic activity, toxicity and phytochemical screening of the hydroalcoholic extract from the leaves of Psidium cattleianum Sabine.
TLDR
The results of the experimental studies proved the analgesic activity of ELPCS and supported the traditional use of this plant. Expand
In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection.
TLDR
The data demonstrate that triterpenes could be interesting compounds to develop therapeutically for the treatment of Chagas' disease and suggest an immunosuppressive effect for UA and OA, which could interfere with host control of parasitemia. Expand
In vitro antiparasitic activity and chemical composition of the essential oil from Protium ovatum leaves (Burceraceae).
TLDR
The essential oil was promising against trypomastigote forms of T. cruzi and L. amazonensis promastigotes and moderate cytotoxicity against LLCMK2 adherent epithelial cell at the concentration range under analysis. Expand
In vitro antiparasitic activity and chemical composition of the essential oil obtained from the fruits of Piper cubeba.
TLDR
The essential oil reported that the essential oil obtained by steam distillation of the fruits of Piper cubeba is active against Schistosoma mansoni is investigated to determine the compounds responsible for the observed activities, as well as its mechanism of action. Expand
Trypanocidal activity and acute toxicity assessment of triterpene acids
TLDR
Results concerning the LD50 assay and the biochemical parameters evaluated in the present study demonstrate that ursolic acid and oleanolic acid can be safely used on an experimental basis. Expand
Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species
TLDR
It has been demonstrated that the presence of ursolic and oleanolic determines this biological activity of the Miconia species, and it is suggested that natural sources display a wide range of secondary metabolites and may play an important role in the discovery of new potential drugs. Expand
In vivo infection by Trypanosoma cruzi: a morphometric study of tissue changes in mice
TLDR
The cytotoxicity assays demonstrated that (−)-cubebin and (−)-hinokinin do not display toxicity and are promising therapeutic agents and could be used in future clinical studies concerning treatment of the Chagas disease. Expand
Chemical composition and biological activities of essential oil from flowers of Psidium guajava (Myrtaceae).
TLDR
Results showed that the PG-EO had strong trypanocidal activity against the trypomastigote forms of Trypanosoma cruzi, promising antibacterial activity against X. fastidiosa and P. carotovorum, and moderate cytotoxicity against LLCMK2 adherent epithelial cells in the concentration range. Expand
(±)-licarin A and its semi-synthetic derivatives: in vitro and in silico evaluation of trypanocidal and schistosomicidal activities.
TLDR
(±)-licarin A 1, a dihydrobenzofuran neolignan, resultant of an oxidative coupling reaction of isoeugenol and horseradish peroxidase (HRP) enzyme is synthesised and three semi-synthetic derivatives from this compound were obtained. Expand
In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni
TLDR
The results suggest that PC-EO possesses an effect against cercariae, schistosomula, and adult worms of the S. mansoni. Expand
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