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Glucose and Endoplasmic Reticulum Calcium Channels Regulate HIF-1β via Presenilin in Pancreatic β-Cells*
Pancreatic β-cell death is a critical event in type 1 diabetes, type 2 diabetes, and clinical islet transplantation. We have previously shown that prolonged block of ryanodine receptor (RyR)-gatedExpand
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Central amplification and fibromyalgia: Disorder of pain processing
Fibromyalgia (FM), a complex chronic pain disorder affecting a heterogeneous patient population, is an area of active basic and clinical research. Although diagnostic criteria for FM have beenExpand
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Prevalence of glucocerebrosidase mutations in the Israeli Ashkenazi Jewish population
Gaucher disease is the most prevalent inherited disease among Ashkenazi Jews. It is very heterogeneous due to a large number of mutations within the glucocerebrosidase gene, whose impaired activityExpand
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Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells
Aims/hypothesisThe pathogenesis of diabetes and the success of islet transplantation depend on the control of pancreatic beta cell fate. The Notch signalling pathway is essential for normal prenatalExpand
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Dual Role of NRSF/REST in Activation and Repression of the Glucocorticoid Response*
Restriction of glutamine synthetase to the nervous system is mainly achieved through the mutual function of the glucocorticoid receptor and the neural restrictive silencing factor, NRSF/REST.Expand
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