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NMR Structure and Action on Nicotinic Acetylcholine Receptors of Water-soluble Domain of Human LYNX1*
TLDR
The NMR spatial structure for the water-soluble domain of human LYNX1 lacking a GPI anchor and its concentration-dependent activity on nicotinic acetylcholine receptors (nAChRs) is reported and computer modeling revealed a possible mode of ws-LYNX1 binding. Expand
The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype
TLDR
Evidence is provided that, by controlling expression of many genes involved in the RSP, the transcriptional repressor REST can regulate this pathway and hence the neurosecretory phenotype and provides further insight into the function of REST. Expand
Utilization of Citrate, Acetylcarnitine, Acetate, Pyruvate and Glucose for the Synthesis of Acetylcholine in Rat Brain Slices
TLDR
The results indicate that earlier evidence led to an underestimation of acetylcar‐nitine as a potential source ofacetyl groups for the synthesis of ACh in mammalian brain; they do not support (but do not disprove) the view that citrate is the main carrier of acetol groups from the intramitochondrial acetyl‐CoA to the extram itochondrial space in cerebral cholinergic neurons. Expand
Muscarinic M2 Receptors Directly Activate Gq/11 and Gs G-Proteins
TLDR
Direct evidence of M2 receptor coupling with the α subunits of Gs and Gq/11 G-proteins is provided and induction of multiple receptor conformational states dependent on both the concentration and the nature of the agonist used is demonstrated. Expand
Detection of choline transporter‐like 1 protein CTL1 in neuroblastoma × glioma cells and in the CNS, and its role in choline uptake
TLDR
The results support the concept that CTL1 protein is necessary for the high affinity choline transport which supplies choline for cell growth and suggests that malfunction of this transporter could have important implications in nervous system development and repair following injury, and in neurodegenerative diseases. Expand
Is an acetylcholine transport system responsible for nonquantal release of acetylcholine at the rodent myoneural junction?
TLDR
The results indicate that the spontaneous release of AcCho from the motor nerve terminals is highly sensitive to low concentrations of specific inhibitors and is probably mediated by a carrier. Expand
Calcium‐Independent Release of Acetylcholine from Electric Organ Synaptosomes and Its Changes by Depolarization and Cholinergic Drugs
TLDR
It is apparent that the spontaneous Ca2+‐independent liberation of ACh from Torpedo synaptosomes is not a simple diffusion and is mediated by a carrier. Expand
Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors
TLDR
The structure and pharmacology of a recombinant analogue of human-secreted Ly-6/uPAR-related protein-2 is described and it is found that SLURP-2 was found to promote the proliferation of human oral keratinocytes via interactions with α3β2-nAChRs, while it inhibited cell growth via α7-n AChRs. Expand
Multiple promoters drive tissue‐specific expression of the human M2 muscarinic acetylcholine receptor gene
TLDR
It is shown that GATA‐4 transcription factor binds to two sites within the regulatory regions of the M2 gene using reporter gene assays, electromobility shift assays and mutational analysis, indicating that transcription initiates much further upstream of the coding region than earlier studies had indicated. Expand
Effects of tetrodotoxin, Ca2+ absence, d‐tubocurarine and vesamicol on spontaneous acetylcholine release from rat muscle.
TLDR
The reduction of spontaneous ACh release observed in the presence of TTX or dTC or in the absence of Ca2+ is best interpreted on the assumption that about 40% of the A Ch release was due to the impulse activity known to be generated in intramuscular motor nerve branches by the ACh which accumulates after the inhibition of cholinesterases. Expand
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