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Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells.
This is the first report demonstrating that ghrelin functions as a key signal, coupling the metabolic axis to the immune system, and supporting the potential use of gh Relin and GHS-R agonists in the management of disease-associated cachexia.
The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance
It is established that calorie restriction and exercise-mediated weight loss in obese individuals with type 2 diabetes is associated with a reduction in adipose tissue expression of Nlrp3 as well as with decreased inflammation and improved insulin sensitivity, and that the NlrP3 inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance.
The ketone metabolite β-hydroxybutyrate blocks NLRP 3 inflammasome – mediated inflammatory disease
The findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NLRP3 inflammasome.
Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma.
Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity.
Ketone body β-hydroxybutyrate blocks the NLRP3 inflammasome-mediated inflammatory disease
In vivo, BHB or a ketogenic diet attenuates caspase-1 activation and IL-1β secretion in mouse models of NLRP3-mediated diseases such as Muckle–Wells syndrome, familial cold autoinflammatory syndrome and urate crystal–induced peritonitis and the findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of theNLRP3 inflammasome.
Uric acid and inflammatory markers.
A positive and significant association between UA and several inflammatory markers was found in a large population-based sample of older persons and in a sub-sample of participants with normal UA, and the prevalence of abnormally high levels of C-reactive protein and IL-6 increased significantly across UA quintiles.
Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance
It is established that ARTs have a restricted TCR-Vβ repertoire, and T cells contribute toward the complex proinflammatory microenvironment of adipose tissue in obesity.
Immunological complications of obesity
Improved understanding of the immunological processes that regulate obesity may yield new treatments for obesity-associated disorders.