• Publications
  • Influence
Protein hydration dynamics in aqueous solution.
Water oxygen-17 and deuteron spin relaxation rates, measured as a function of resonance frequency, have been used to study the dynamics of protein hydration in aqueous solutions of ribonuclease A,Expand
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  • 7
Water and monovalent ions in the minor groove of B-DNA oligonucleotides as seen by NMR.
During the past 8 years, two complementary nmr techniques-magnetic relaxation dispersion and nuclear Overhauser effect spectroscopy-have been applied extensively to the study of water and monovalentExpand
  • 82
  • 5
  • Open Access
Hydration of denatured and molten globule proteins
The hydration of nonnative states is central to protein folding and stability but has been probed mainly by indirect methods. Here we use water 17O relaxation dispersion to monitor directly theExpand
  • 153
  • 4
  • Open Access
Kinetics of DNA hydration.
The hydration of the d(CGCGAATTCGCG) B-DNA duplex in solution was studied by nuclear magnetic relaxation dispersion (NMRD) of the water nuclei 1H, 2H, and 17O, and by nuclear Overhauser effectsExpand
  • 110
  • 3
  • Open Access
Sequence-specific binding of counterions to B-DNA.
  • V. Denisov, B. Halle
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences…
  • 18 January 2000
Recent studies by x-ray crystallography, NMR, and molecular simulations have suggested that monovalent counterions can penetrate deeply into the minor groove of B form DNA. Such groove-bound ionsExpand
  • 136
  • 3
  • Open Access
Hydrogen exchange and protein hydration: the deuteron spin relaxation dispersions of bovine pancreatic trypsin inhibitor and ubiquitin.
Water deuteron (2H) spin relaxation was used to study hydrogen exchange, hydration, and protein dynamics in aqueous solutions of the globular proteins bovine pancreatic trypsin inhibitor (BPTI) andExpand
  • 72
  • 3
  • Open Access
Using buried water molecules to explore the energy landscape of proteins
Buried water molecules constitute a highly conserved, integral part of nearly all known protein structures. Such water molecules exchange with external solvent as a result of protein conformationalExpand
  • 135
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Protein hydration dynamics in aqueous solution: a comparison of bovine pancreatic trypsin inhibitor and ubiquitin by oxygen-17 spin relaxation dispersion.
Water oxygen-17 spin relaxation was used to study hydration and dynamics of the globular proteins bovine pancreatic trypsin inhibitor (BPTI) and ubiquitin in aqueous solution. The frequencyExpand
  • 129
  • 2
  • Open Access
Orientational Disorder and Entropy of Water in Protein Cavities
Water 17O, 2H, and 1H nuclear magnetic relaxation dispersion (NMRD) data are presented for the Y35G mutant of bovine pancreatic trypsin inhibitor (BPTI) in aqueous solution. The NMRD data show thatExpand
  • 86
  • 2
  • Open Access
Stabilization of internal charges in a protein: water penetration or conformational change?
The ionizable amino acid side chains of proteins are usually located at the surface. However, in some proteins an ionizable group is embedded in an apolar internal region. Such buried ionizableExpand
  • 42
  • 2
  • Open Access