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Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR
- V. Corman, O. Landt, C. Drosten
- Medicine, BiologyEuro surveillance : bulletin Europeen sur les…
- 1 January 2020
A validated diagnostic workflow for 2019-nCoV is presented, its design relying on close genetic relatedness of 2019- nCoV with SARS coronavirus, making use of synthetic nucleic acid technology.
Virological assessment of hospitalized patients with COVID-2019
Detailed virological analysis of nine cases of coronavirus disease 2019 (COVID-19) provides proof of active replication of the SARS-CoV-2 virus in tissues of the upper respiratory tract.
Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction.
- V. Corman, I. Eckerle, C. Drosten
- BiologyEuro surveillance : bulletin Europeen sur les…
- 27 September 2012
Two real-time reverse-transcription polymerase chain reaction assays for a novel human coronavirus, targeting regions upstream of the E gene (upE) or within open reading frame (ORF)1b, respectively, observed no cross-reactivity with coronaviruses OC43, NL63, 229E, SARS-CoV or with 92 clinical specimens containing common human respiratory viruses.
Hosts and Sources of Endemic Human Coronaviruses
Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19
CD4 + T cells that are reactive against the spike glycoprotein of SARS-CoV-2 in the peripheral blood of patients with COVID-19 and healthy donors are found, indicating that spike-protein cross-reactive T cells are present and probably generated during previous encounters with endemic coronaviruses.
Genomic Characterization of Severe Acute Respiratory Syndrome-Related Coronavirus in European Bats and Classification of Coronaviruses Based on Partial RNA-Dependent RNA Polymerase Gene Sequences
An evaluation of CoV in rhinolophid and vespertilionid bat species common in Europe found that proteins 3b and 6 were highly divergent from those proteins in all known SARS-related CoV, highlighting the importance of assessments of the zoonotic potential of widely distributed bat-borne CoV.
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.
The morphological changes associated with infection such as thromboembolic ischemic infarction of the CNS and evidence of SARS-CoV-2 neurotropism are described and presented.
Rooting the Phylogenetic Tree of Middle East Respiratory Syndrome Coronavirus by Characterization of a Conspecific Virus from an African Bat
The full genome sequence of a CoV was determined directly from fecal material obtained from a South African Neoromicia capensis bat, providing evidence for the evolution of MERS-CoV in camels that preceded that in humans and suggesting that humans are infected by camels rather than vice versa.